Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1990 Jul;4(2):137-49.
doi: 10.1007/BF00678405.

Molecular analysis of structural protein genes of the Yamagata-1 strain of defective subacute sclerosing panencephalitis virus. I. Nucleotide sequence of the nucleoprotein gene

K Komase  1 , T Kasaoka, Y Yoshikawa, T A Sato, K Yamanouchi
Affiliations

Molecular analysis of structural protein genes of the Yamagata-1 strain of defective subacute sclerosing panencephalitis virus. I. Nucleotide sequence of the nucleoprotein gene

K Komase et al. Virus Genes. 1990 Jul.

Abstract

The complete nucleotide sequence of cloned cDNAs corresponding to the full-length mRNA encoding the NP protein of the Yamagata-1 strain of subacute sclerosing panencephalitis (SSPE) virus was determined. The gene is composed of 1683 nucleotides and contains a single large open reading frame, which is capable of encoding 525 amino acids with a molecular weight of 58,399. Comparison of the nucleotide and predicted amino acid sequences with those of the Edmonston strain of measles virus (MV) showed that the gene and the protein were highly conserved. However, the antigenic sites on the NP protein of the Yamagata-1 strain were found to be changed by an epitope analysis using monoclonal antibodies against the NP protein of MV. Only 1 of 4 monoclonal antibodies reacted with the NP protein of SSPE virus, and the other three antibodies did not. Almost identical changes in nucleotides and amino acids were found to occur in the NP gene of the Yamagata-1 strain when compared with the IP-3-Ca strain of another SSPE virus. In addition, the deduced secondary structure of the NP protein of the IP-3-Ca strain was similar to that of the Yamagata-1 strain, but differed from the MV. These results suggest that the NP proteins of SSPE viruses have a common property that is different from MV.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. J Gen Virol. 1985 Jul;66 ( Pt 7):1397-409 - PubMed
    1. J Gen Virol. 1989 Feb;70 ( Pt 2):435-41 - PubMed
    1. J Virol. 1979 Oct;32(1):329-33 - PubMed
    1. Prog Med Virol. 1982;28:65-95 - PubMed
    1. J Gen Virol. 1986 Sep;67 ( Pt 9):1987-92 - PubMed

Publication types

MeSH terms

LinkOut - more resources