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Comment
. 2006 Sep 19;16(18):R812-5.
doi: 10.1016/j.cub.2006.08.040.

Calcium signaling: double duty for calcium at the mitochondrial uniporter

James W Putney Jr  1 , Andrew P Thomas
Affiliations
Comment

Calcium signaling: double duty for calcium at the mitochondrial uniporter

James W Putney Jr et al. Curr Biol. .

Abstract

Uptake of Ca(2+) by mitochondria serves as a regulator of a number of important cellular functions, including energy metabolism, cytoplasmic Ca(2+) signals, and apoptosis. Recent findings reveal that the process of Ca(2+) uptake by the mitochondrial uniporter is itself regulated by Ca(2+) in a temporally complex manner.

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Figures

Figure 1
Figure 1
Regulation of mitochondrial Ca2+ uptake. Close apposition between mitochondria and endoplasmic reticulum (ER) Ca2+ release sites facilitates Ca2+ uptake into the mitochondria. A fast activation of the uniporter, mediated by calmodulin (CaM), enhances mitochondrial Ca2+ accumulation. A slower Ca2+-dependent inactivation of the uniporter serves to limit mitochondrial Ca2+ uptake during a prolonged rise of cytosolic Ca2+. The fast activation allows the mitochondrial matrix [Ca2+] to closely follow changes in the cytosolic [Ca2+], as occurs during cytosolic Ca2+ oscillations (left inset). The slower inactivation process limits mitochondrial Ca2+ uptake when the elevation of cytosolic Ca2+ is more sustained (right inset). (1) SERCA Ca2+ pump, (2) IP3 receptor Ca2+ release channel, (3) Ca2+ uniporter, (4) mitochondrial Ca2+/Na+ exchanger, (5) mitochondrial Ca2+/H+ exchanger, (6) ATP synthetase. The mitochondrial respiratory chain is shown as 3 cycles of proton pumping from the matrix.
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