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. 2006 Oct;11(7):864-9.
doi: 10.1177/1087057106292473. Epub 2006 Sep 14.

High-throughput screening: update on practices and success

Sandra Fox  1 , Shauna Farr-Jones, Lynne Sopchak, Amy Boggs, Helen Wang Nicely, Richard Khoury, Michael Biros
Affiliations

High-throughput screening: update on practices and success

Sandra Fox et al. J Biomol Screen. 2006 Oct.

Abstract

High-throughput screening (HTS) has become an important part of drug discovery at most pharmaceutical and many biotechnology companies worldwide, and use of HTS technologies is expanding into new areas. Target validation, assay development, secondary screening, ADME/Tox, and lead optimization are among the areas in which there is an increasing use of HTS technologies. It is becoming fully integrated within drug discovery, both upstream and downstream, which includes increasing use of cell-based assays and high-content screening (HCS) technologies to achieve more physiologically relevant results and to find higher quality leads. In addition, HTS laboratories are continually evaluating new technologies as they struggle to increase their success rate for finding drug candidates. The material in this article is based on a 900-page HTS industry report involving 54 HTS directors representing 58 HTS laboratories and 34 suppliers.

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