Comparative Study
doi: 10.1097/01.wnr.0000234747.73312.e7.
Astrocytogenesis of embryonic stem-cell-derived neural stem cells: Default differentiation
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- PMID: 16957601
- DOI: 10.1097/01.wnr.0000234747.73312.e7
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Comparative Study
Astrocytogenesis of embryonic stem-cell-derived neural stem cells: Default differentiation
Neuroreport.
.
Abstract
Neural stem cells differentiate from embryonic stem cells via formation of neural stem spheres under free-floating conditions in astrocyte-conditioned medium. Subsequent culture of neural stem spheres on an adhesive substrate with fibroblast growth factor-2 promotes the migration of neural stem cells onto the substrate, resulting in an increase in the number of cells. These embryonic stem cell-derived neural stem cells can be differentiated almost exclusively into astrocytes by withdrawing fibroblast growth factor-2 from the medium without any additional instructions.
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