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Review
. 2006 Oct;28(2):97-107.
doi: 10.1007/s00281-006-0031-6. Epub 2006 Aug 29.

Current topics in human SLE genetics

Maida Wong  1 , Betty P Tsao
Affiliations
Review

Current topics in human SLE genetics

Maida Wong et al. Springer Semin Immunopathol. 2006 Oct.

Abstract

Susceptibility to systemic lupus erythematosus (SLE) depends on genetic and environmental factors. Genome scan studies have identified eight chromosomal regions with significant linkage to SLE that are confirmed by individual cohorts, suggesting that susceptibility genes may be identified within each of these loci. Linkage studies and single nucleotide polymorphisms (SNPs) have led to the identification of positional candidate genes, and their functional allelic variants have demonstrated molecular pathogenesis of the disease. The discovery of positional candidate genes that are associated with various autoimmune diseases signifies a common pathway in the mechanism of these diseases. Copy polymorphisms in susceptibility genes provide evidence in how genetic plasticity affects complex phenotypes as seen in SLE.

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References

    1. Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9465-70 - PubMed
    1. Rheumatology (Oxford). 2003 Mar;42(3):446-52 - PubMed
    1. Curr Opin Rheumatol. 1998 Sep;10(5):399-408 - PubMed
    1. Nat Genet. 2006 May;38(5):550-5 - PubMed
    1. J Biol Chem. 2000 Mar 24;275(12):9043-6 - PubMed

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