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Review
. 2006 Oct;41(10):894-903.
doi: 10.1016/j.exger.2006.06.054. Epub 2006 Aug 21.

The trifecta of aging in Caenorhabditis elegans

Suzanne Wolff  1 , Andrew Dillin
Affiliations
Review

The trifecta of aging in Caenorhabditis elegans

Suzanne Wolff et al. Exp Gerontol. 2006 Oct.

Abstract

Insulin signaling, mitochondrial respiration, and dietary restriction share conserved roles not only in the regulation of lifespan, but also in the timing and control of diverse functions such as reproduction, stress resistance and metabolism. These autonomous pathways differ in their dependence on known transcription factors and in their temporal requirements, but converge to manipulate the core set of physiological systems necessary for extended lifespan in worms. Recent work suggests that components of these pleiotrophic pathways might be manipulated specifically for their effects on aging without affecting additional downstream functions. Examination of these findings will help us to understand how the molecular mechanisms of distinct pathways can unite in the regulation of longevity.

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