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Review
. 2006;35(3-4):297-325.
doi: 10.1080/08820130600754960.

More than structural cells, fibroblasts create and orchestrate the tumor microenvironment

Carolyn J Baglole  1 , Denise M Ray, Steven H Bernstein, Steven E Feldon, Terry J Smith, Patricia J Sime, Richard P Phipps
Affiliations
Review

More than structural cells, fibroblasts create and orchestrate the tumor microenvironment

Carolyn J Baglole et al. Immunol Invest. 2006.

Abstract

The tumor microenvironment comprises many cell types including infiltrating immune cells such as lymphocytes, endothelial cells and a complex stroma consisting mainly of fibroblasts. Fibroblasts are heterogeneous and consist of Thy-1+ and Thy-1- subsets that define different biosynthetic and differentiation potential. They produce mediators linked to carcinogenesis and metastasis, including Cox-2 and PGE2, both of which are also increased in most cancers. This review will highlight the emerging role of the complex fibroblastic stroma in establishing a microenvironment supporting malignant transformation, tumor growth and attenuation of host anti-tumor immune responses.

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