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Review
. 2006 Oct;11(7):803-10.
doi: 10.1007/s00775-006-0125-6. Epub 2006 Jul 26.

Ferritins: iron/oxygen biominerals in protein nanocages

Elizabeth C Theil  1 , Manolis Matzapetakis, Xiaofeng Liu
Affiliations
Review

Ferritins: iron/oxygen biominerals in protein nanocages

Elizabeth C Theil et al. J Biol Inorg Chem. 2006 Oct.

Abstract

Ferritin protein nanocages that form iron oxy biominerals in the central nanometer cavity are nature's answer to managing iron and oxygen; gene deletions are lethal in mammals and render bacteria more vulnerable to host release of antipathogen oxidants. The multifunctional, multisubunit proteins couple iron with oxygen (maxi-ferritins) or hydrogen peroxide (mini-ferritins) at catalytic sites that are related to di-iron sites oxidases, ribonucleotide reductase, methane monooxygenase and fatty acid desaturases, and synthesize mineral precursors. Gated pores, distributed symmetrically around the ferritin cages, control removal of iron by reductants and chelators. Gene regulation of ferritin, long known to depend on iron and, in animals, on a noncoding messenger RNA (mRNA) structure linked in a combinatorial array to functionally related mRNA of iron transport, has recently been shown to be linked to an array of proteins for antioxidant responses such as thioredoxin and quinone reductases. Ferritin DNA responds more to oxygen signals, and ferritin mRNA responds more to iron signals. Ferritin genes (DNA and RNA) and protein function at the intersection of iron and oxygen chemistry in biology.

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