Peptides for disruption of PKA anchoring
- PMID: 16856835
- DOI: 10.1042/BST0340472
Peptides for disruption of PKA anchoring
Abstract
Adaptor or scaffolding proteins are at the basis of multiprotein complexes that spatially and temporally co-ordinate the propagation and integration of a broad range of cellular events. One class of scaffolding proteins are AKAPs (A-kinase-anchoring proteins). They sequester PKA (protein kinase A) and other signalling molecules including phosphodiesterases, other protein kinases and protein phosphatases to specific subcellular compartments. AKAP-dependent protein-protein interactions play a role in many physiologically relevant processes. For example, AKAP-PKA interactions are essential for the vasopressin-mediated water re-absorption in renal collecting duct principal cells or beta-adrenoceptor-induced increases in cardiac myocyte contractility. Here, we discuss recently developed peptide disruptors of AKAP-PKA interactions. Such peptides are valuable tools to study the relevance of PKA anchoring in cellular processes.
Similar articles
-
Molecular basis of AKAP specificity for PKA regulatory subunits.Mol Cell. 2006 Nov 3;24(3):383-95. doi: 10.1016/j.molcel.2006.09.006. Mol Cell. 2006. PMID: 17081989
-
Analysis of A-kinase anchoring protein (AKAP) interaction with protein kinase A (PKA) regulatory subunits: PKA isoform specificity in AKAP binding.J Mol Biol. 2000 Apr 28;298(2):329-39. doi: 10.1006/jmbi.2000.3662. J Mol Biol. 2000. PMID: 10764601
-
Direct AKAP-mediated protein-protein interactions as potential drug targets.Handb Exp Pharmacol. 2008;(186):483-503. doi: 10.1007/978-3-540-72843-6_20. Handb Exp Pharmacol. 2008. PMID: 18491065 Review.
-
Characterization of A-kinase-anchoring disruptors using a solution-based assay.Biochem J. 2006 Dec 15;400(3):493-9. doi: 10.1042/BJ20060962. Biochem J. 2006. PMID: 16948636 Free PMC article.
-
A-kinase anchoring protein targeting of protein kinase A in the heart.J Mol Cell Cardiol. 2004 Sep;37(3):653-65. doi: 10.1016/j.yjmcc.2004.04.017. J Mol Cell Cardiol. 2004. PMID: 15350838 Review.
Cited by
-
Adrenergic Regulation of Calcium Channels in the Heart.Annu Rev Physiol. 2022 Feb 10;84:285-306. doi: 10.1146/annurev-physiol-060121-041653. Epub 2021 Nov 9. Annu Rev Physiol. 2022. PMID: 34752709 Free PMC article. Review.
-
Protein kinase A anchoring via AKAP150 is essential for TRPV1 modulation by forskolin and prostaglandin E2 in mouse sensory neurons.J Neurosci. 2008 May 7;28(19):4904-17. doi: 10.1523/JNEUROSCI.0233-08.2008. J Neurosci. 2008. PMID: 18463244 Free PMC article.
-
Cyclin-Dependent Kinase 18 Controls Trafficking of Aquaporin-2 and Its Abundance through Ubiquitin Ligase STUB1, Which Functions as an AKAP.Cells. 2020 Mar 10;9(3):673. doi: 10.3390/cells9030673. Cells. 2020. PMID: 32164329 Free PMC article.
-
Protein kinase A activity and anchoring are required for ovarian cancer cell migration and invasion.PLoS One. 2011;6(10):e26552. doi: 10.1371/journal.pone.0026552. Epub 2011 Oct 19. PLoS One. 2011. PMID: 22028904 Free PMC article.
-
Neurochondrin is an atypical RIIα-specific A-kinase anchoring protein.Biochim Biophys Acta. 2015 Oct;1854(10 Pt B):1667-75. doi: 10.1016/j.bbapap.2015.04.018. Epub 2015 Apr 23. Biochim Biophys Acta. 2015. PMID: 25916936 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
