doi: 10.1016/0140-6736(91)92302-i.
First-pass metabolism of cyclosporin by the gut
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- PMID: 1683920
- DOI: 10.1016/0140-6736(91)92302-i
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First-pass metabolism of cyclosporin by the gut
Lancet.
.
Free article
Abstract
Cyclosporin is thought to be exclusively metabolised in the liver. We instilled cyclosporin into the small bowel of 2 patients during the anhepatic phase of liver transplantation; cyclosporin metabolites were readily detected in portal venous blood. Our findings indicate that the small intestine is a major site of cyclosporin breakdown: such intestinal metabolism might help to explain the poor oral bioavailability and drug interactions of cyclosporin.
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