Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2006 Jul;13(7):715-21.
doi: 10.1128/CVI.00052-06.

Defective virus drives human immunodeficiency virus infection, persistence, and pathogenesis

Diana Finzi  1 , Susan F Plaeger, Carl W Dieffenbach
Affiliations
Review

Defective virus drives human immunodeficiency virus infection, persistence, and pathogenesis

Diana Finzi et al. Clin Vaccine Immunol. 2006 Jul.
No abstract available

PubMed Disclaimer

Figures

FIG. 1.
FIG. 1.
Resting CD4 T cells must be activated to produce virus. (a) HIV is most likely to infect a resting CD4 T cell. (b) Resting CD4 T cells are not permissive to HIV replication, and the PIC degrades in the cytoplasm of resting CD4 T cells. (c) Activation of the resting cell is necessary for viral replication to occur. (d) An uninfected resting cell that becomes activated can be productively infected regardless of its antigenic specificity. (e) Rarely, activated infected cells survive and become long-lived memory cells with integrated, latent provirus. (f) Reactivation of these cells also makes them permissive to HIV replication.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Albert, J., B. Abrahamsson, K. Nagy, E. Aurelius, H. Gaines, G. Nystrom, and E. M. Fenyo. 1990. Rapid development of isolate-specific neutralizing antibodies after primary HIV-1 infection and consequent emergence of virus variants which resist neutralization by autologous sera. AIDS 4:107-112. - PubMed
    1. Allen, T. M., M. Altfeld, S. C. Geer, E. T. Kalife, C. Moore, K. M. O'Sullivan, I. Desouza, M. E. Feeney, R. L. Eldridge, E. L. Maier, D. E. Kaufmann, M. P. Lahaie, L. Reyor, G. Tanzi, M. N. Johnston, C. Brander, R. Draenert, J. K. Rockstroh, H. Jessen, E. S. Rosenberg, S. A. Mallal, and B. D. Walker. 2005. Selective escape from CD8+ T-cell responses represents a major driving force of human immunodeficiency virus type 1 (HIV-1) sequence diversity and reveals constraints on HIV-1 evolution. J. Virol. 79:13239-13249. - PMC - PubMed
    1. Arendrup, M., C. Nielsen, J. E. Hansen, C. Pedersen, L. Mathiesen, and J. O. Nielsen. 1992. Autologous HIV-1 neutralizing antibodies: emergence of neutralization-resistant escape virus and subsequent development of escape virus neutralizing antibodies. J. Acquir. Immune Defic. Syndr. 5:303-307. - PubMed
    1. Bagasra, O., S. P. Hauptman, H. W. Lischner, M. Sachs, and R. J. Pomerantz. 1992. Detection of human immunodeficiency virus type 1 provirus in mononuclear cells by in situ polymerase chain reaction. N. Engl. J. Med. 326:1385-1391. - PubMed
    1. Bebenek, K., J. Abbotts, J. D. Roberts, S. H. Wilson, and T. A. Kunkel. 1989. Specificity and mechanism of error-prone replication by human immunodeficiency virus-1 reverse transcriptase. J. Biol. Chem. 264:16948-16956. - PubMed