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Comparative Study
. 2006 Jul;67(7):521-6.
doi: 10.1016/j.humimm.2006.04.001. Epub 2006 May 3.

A role for KIR gene variants other than KIR2DS1 in conferring susceptibility to psoriasis

Rafal Płoski  1 , Wioleta Luszczek, Piotr Kuśnierczyk, Piotr Nockowski, Maria Cisło, Paweł Krajewski, Jacek Malejczyk
Affiliations
Comparative Study

A role for KIR gene variants other than KIR2DS1 in conferring susceptibility to psoriasis

Rafal Płoski et al. Hum Immunol. 2006 Jul.

Abstract

Recently we described an association between psoriasis and KIR2DS1, a gene for a stimulatory natural killer cell receptor, in a Polish population. The association was independently reported among Japanese and confirmed in a U.S. population. Prompted by these findings, we reanalyzed data by a multivariate approach in search of possible effects of KIR genes other than KIR2DS1 (non-KIR2DS1). The methodology was based on a stratified analysis and multiple logistic regression. We found that the non-KIR2DS1 genes had joint effects comparable to or stronger than the effects of KIR2DS1 in both the fraction of explained variance (0.174 vs 0.204, respectively, for KIR2DS1 and non-KIR2DS1) and the statistical significance (p = 0.000008 vs p = 0.000001, respectively). When individual genes were considered, a decrease in KIR2DS5 among patients vs controls (OR = 0.2, pcor = 0.0005) and a decrease in KIR2DS3 restricted to KIR2DS1-positive individuals (OR = 0.2, pcor = 0.005) were evident. We also performed a multivariate analysis of the HLA-Cw genotypes but failed to demonstrate any effects in addition to the known association with HLA-Cw*06. We conclude that the effect of the KIR genes on psoriasis susceptibility is complex, extending beyond the association with KIR2DS1 and involving protective effects and interactions.

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