Review
doi: 10.1146/annurev.genet.40.110405.090428.
Cellular responses to DNA damage: one signal, multiple choices
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- PMID: 16805666
- DOI: 10.1146/annurev.genet.40.110405.090428
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Review
Cellular responses to DNA damage: one signal, multiple choices
Annu Rev Genet.
2006.
Abstract
DNA double-strand breaks (DSBs) produce a number of cellular responses, some mutually exclusive. Depending on where on the chromosome it occurs, a DSB may become preserved inside a telomere or eliminated by repair. A cell may arrest division via checkpoint activation to fix DSBs or commit suicide by apoptosis. What determines the outcome: to bury, fix, or succumb to DNA DSBs? With this question in mind, we review recent data on cellular responses to DSBs.
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