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Review
. 2006 May;1067(1):500-5.
doi: 10.1196/annals.1354.072.

Severe acute respiratory syndrome (SARS): development of diagnostics and antivirals

Morten Draeby Sørensen  1 , Brian Sørensen, Regina Gonzalez-Dosal, Connie Jenning Melchjorsen, Jens Weibel, Jing Wang, Chen Wie Jun, Yang Huanming, Peter Kristensen
Affiliations
Review

Severe acute respiratory syndrome (SARS): development of diagnostics and antivirals

Morten Draeby Sørensen et al. Ann N Y Acad Sci. 2006 May.

Abstract

The previously unknown coronavirus that caused severe acute respiratory syndrome (SARS-CoV) affected more than 8,000 persons worldwide and was responsible for more than 700 deaths during the first outbreak in 2002-2003. For reasons unknown, the SARS virus is less severe and the clinical progression a great deal milder in children younger than 12 years of age. In contrast, the mortality rate can exceed 50% for persons at or above the age of 60. As part of the Sino-European Project on SARS Diagnostics and Antivirals (SEPSDA), an immune phage-display library is being created from convalescent patients in a phagemid system for the selection of single-chain fragment variables (scFv) antibodies recognizing the SARS-CoV.

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