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. 1991 Aug 15;178(3):1413-20.
doi: 10.1016/0006-291x(91)91051-d.

Deletion-mutant epidermal growth factor receptor in human gliomas: effects of type II mutation on receptor function

P A Humphrey  1 , L M Gangarosa, A J Wong, G E Archer, M Lund-Johansen, R Bjerkvig, O D Laerum, H S Friedman, D D Bigner
Affiliations

Deletion-mutant epidermal growth factor receptor in human gliomas: effects of type II mutation on receptor function

P A Humphrey et al. Biochem Biophys Res Commun. .

Abstract

Malignant human glioma D-298 MG amplifies a rearranged epidermal growth factor receptor (EGFR) gene (c-erbB proto-oncogene), resulting in an in-frame deletion of 83 amino acids in domain IV of the extracellular domain of the EGFR. EGF and transforming growth factor-a (TGF-a) bound to the mutant EGFR with high affinity and enhanced the intrinsic mutant EGFR kinase activity. The mutant EGFR was capable of transducing EGF-stimulated glioma cell proliferation and invasiveness in an in vitro three-dimensional spheroid model. The deletion-mutant EGFR in D-298 MG is capable of being activated by growth factor; this suggests that overexpression of this mutant EGFR protein rather than structural alteration may be the more significant biologic event.

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