Tacrolimus ointment 0.1% alone and in combination with medium-dose UVA1 in the treatment of palmar or plantar psoriasis
- PMID: 16774101
Tacrolimus ointment 0.1% alone and in combination with medium-dose UVA1 in the treatment of palmar or plantar psoriasis
Abstract
Psoriasis is a common skin condition affecting approximately 2.6% of the population in the US. The most effective current therapies for psoriasis have suppressive activity against T lymphocytes directly or by modulating the biologic effects of inflammatory cytokines. Tacrolimus has been used successfully to treat a number of T cell-mediated diseases. UVA1 has been shown to induce T lymphocyte apoptosis. Combination treatment is commonly used in the management of psoriasis. Therefore, this pilot study was performed to evaluate if the combination of medium-dose UVA1 (50 J/cm2) and tacrolimus ointment is effective for the treatment of palmar plantar psoriasis. A total of 5 patients completed the study of 30 UVA1 treatments, and another patient completed half of the treatments. No dramatic changes in plaque thickness or scaling were seen with either tacrolimus alone or with the combination of tacrolimus and medium dose UVA1 on palmar or plantar psoriasis.
Similar articles
-
Tacrolimus ointment is effective for facial and intertriginous psoriasis.J Am Acad Dermatol. 2004 Nov;51(5):723-30. doi: 10.1016/j.jaad.2004.07.011. J Am Acad Dermatol. 2004. PMID: 15523350 Clinical Trial.
-
Topical tacrolimus ointment combined with 6% salicylic acid gel for plaque psoriasis treatment.Arch Dermatol. 2005 Jan;141(1):43-6. doi: 10.1001/archderm.141.1.43. Arch Dermatol. 2005. PMID: 15655140 Clinical Trial.
-
Preliminary study of the efficacy and tolerability of combination therapy with calcipotriene ointment 0.005% and tacrolimus ointment 0.1% in the treatment of stable plaque psoriasis.Cutis. 2012 Sep;90(3):140-4. Cutis. 2012. PMID: 23094314 Clinical Trial.
-
Clobetasol propionate for psoriasis: are ointments really more potent?J Drugs Dermatol. 2006 Jun;5(6):527-32. J Drugs Dermatol. 2006. PMID: 16774104 Review.
-
[Current treatment of psoriasis].Duodecim. 2000;116(24):2769-75; quiz 2776, 2787. Duodecim. 2000. PMID: 12077879 Review. Finnish. No abstract available.
Cited by
-
Palmoplantar psoriasis is associated with greater impairment of health-related quality of life compared with moderate to severe plaque psoriasis.J Am Acad Dermatol. 2014 Oct;71(4):623-32. doi: 10.1016/j.jaad.2014.04.063. Epub 2014 Jun 2. J Am Acad Dermatol. 2014. PMID: 24894455 Free PMC article.
-
Tacrolimus for the management of psoriasis: clinical utility and place in therapy.Psoriasis (Auckl). 2016 Dec 7;6:153-163. doi: 10.2147/PTT.S101233. eCollection 2016. Psoriasis (Auckl). 2016. PMID: 29387602 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Medical