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Comment
. 2006;5(4):10.
doi: 10.1186/jbiol44. Epub 2006 Jun 8.

The interaction map of yeast: terra incognita?

Joe Mellor  1 , Charles DeLisi
Affiliations
Comment

The interaction map of yeast: terra incognita?

Joe Mellor et al. J Biol. 2006.

Abstract

A systematic curation of the literature on Saccharomyces cerevisiae has yielded a comprehensive collection of experimentally observed interactions. This new resource augments current views of the topological structure of yeast's physical and genetic networks, but also reveals that existing studies cover only a fraction of the cell.

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Figures

Figure 1
Figure 1
Topological view of the curated protein-protein network of yeast interactions. Adapted from data in Reguly and Breitkreutz et al. [1]. Links are curated from thousands of literature articles referencing proteins in the Saccharoymyces cerevisiae genome. Links shown in black are interactions also recovered by any of five commonly used datasets derived from high-throughput yeast two-hybrid or mass spectrometric screening techniques. Visualization was performed with the VisANT analysis tool [19].
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References

    1. Reguly T, Breitkreutz A, Boucher L, Breitkreutz BJ, Hon GC, Myers CL, Parsons A, Friesen H, Oughtred R, Tong A, Stark C, Ho Y, Botstein D, Andrews B, Boone C, Troyanskya OG, Ideker T, Dolinski K, Batada NN, Tyers M. Comprehensive curation and analysis of global interaction networks in Saccharomyces cerevisiae. J Biol. 2006;5:11. doi: 10.1186/jbiol36. - DOI - PMC - PubMed
    1. Gavin AC, Bosche M, Krause R, Grandi P, Marzioch M, Bauer A, Schultz J, Rick JM, Michon AM, Cruciat CM, et al. Functional organization of the yeast proteome by systematic analysis of protein complexes. Nature. 2002;415:141–147. doi: 10.1038/415141a. - DOI - PubMed
    1. Ho Y, Gruhler A, Heilbut A, Bader GD, Moore L, Adams SL, Millar A, Taylor P, Bennett K, Boutilier K, et al. Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002;415:180–183. doi: 10.1038/415180a. - DOI - PubMed
    1. Ito T, Chiba T, Ozawa R, Yoshida M, Hattori M, Sakaki Y. A comprehensive two-hybrid analysis to explore the yeast protein interactome. Proc Natl Acad Sci USA. 2001;98:4569–4574. doi: 10.1073/pnas.061034498. - DOI - PMC - PubMed
    1. Ito T, Tashiro K, Muta S, Ozawa R, Chiba T, Nishizawa M, Yamamoto K, Kuhara S, Sakaki Y. Toward a protein-protein interaction map of the budding yeast: A comprehensive system to examine two-hybrid interactions in all possible combinations between the yeast proteins. Proc Natl Acad Sci USA. 2000;97:1143–1147. doi: 10.1073/pnas.97.3.1143. - DOI - PMC - PubMed

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