This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features!

Skip to main page content

Email citation

Add to Collections

Your saved search

Name of saved search:

Search terms:

Test search terms

Would you like email updates of new search results?

Yes
No

Email: (change)

Frequency:

Which day?

Which day?

Report format:

Send at most:

Send even when there aren't any new results

Optional text in email:

Your RSS Feed

Review

. 2006 Jun 1;49(11):3033-44.

doi: 10.1021/jm0512903.

Medicinal chemistry of combretastatin A4: present and future directions

Gian Cesare Tron¹, Tracey Pirali, Giovanni Sorba, Francesca Pagliai, Sara Busacca, Armando A Genazzani

Affiliations

Affiliation

¹ Dipartimento di Scienze Chimiche, Alimentari, Farmaceutiche e Farmacologiche and Drug and Food Biotechnology Center, Università degli Studi del Piemonte Orientale A. Avogadro, Via Bovio 6, 28100 Novara, Italy. tron@pharm.unipmn.it

PMID: 16722619
DOI: 10.1021/jm0512903

Review

Medicinal chemistry of combretastatin A4: present and future directions

Gian Cesare Tron et al. J Med Chem. 2006.

. 2006 Jun 1;49(11):3033-44.

doi: 10.1021/jm0512903.

Authors

Gian Cesare Tron¹, Tracey Pirali, Giovanni Sorba, Francesca Pagliai, Sara Busacca, Armando A Genazzani

Affiliation

¹ Dipartimento di Scienze Chimiche, Alimentari, Farmaceutiche e Farmacologiche and Drug and Food Biotechnology Center, Università degli Studi del Piemonte Orientale A. Avogadro, Via Bovio 6, 28100 Novara, Italy. tron@pharm.unipmn.it

PMID: 16722619
DOI: 10.1021/jm0512903

No abstract available

PubMed Disclaimer

Similar articles

Synthesis and biological evaluation of vinylogous combretastatin A-4 derivatives.
Kaffy J, Pontikis R, Florent JC, Monneret C. Kaffy J, et al. Org Biomol Chem. 2005 Jul 21;3(14):2657-60. doi: 10.1039/b505955k. Epub 2005 Jun 21. Org Biomol Chem. 2005. PMID: 15999202
Antimitotic and cell growth inhibitory properties of combretastatin A-4-like ethers.
Lawrence NJ, Rennison D, Woo M, McGown AT, Hadfield JA. Lawrence NJ, et al. Bioorg Med Chem Lett. 2001 Jan 8;11(1):51-4. doi: 10.1016/s0960-894x(00)00596-5. Bioorg Med Chem Lett. 2001. PMID: 11140732
1,2,3,4-tetrahydro-2-thioxopyrimidine analogs of combretastatin-A4.
Lee L, Davis R, Vanderham J, Hills P, Mackay H, Brown T, Mooberry SL, Lee M. Lee L, et al. Eur J Med Chem. 2008 Sep;43(9):2011-5. doi: 10.1016/j.ejmech.2007.11.030. Epub 2007 Dec 14. Eur J Med Chem. 2008. PMID: 18226429
Plant-based anticancer molecules: a chemical and biological profile of some important leads.
Srivastava V, Negi AS, Kumar JK, Gupta MM, Khanuja SP. Srivastava V, et al. Bioorg Med Chem. 2005 Nov 1;13(21):5892-908. doi: 10.1016/j.bmc.2005.05.066. Bioorg Med Chem. 2005. PMID: 16129603 Review.
[Spectral characteristics, biogenesis and biological activities of oligostilbenes].
Li XM, Li N, Huang KS, Lin M. Li XM, et al. Yao Xue Xue Bao. 2002 Jan;37(1):69-74. Yao Xue Xue Bao. 2002. PMID: 12579904 Review. Chinese. No abstract available.

See all similar articles

Cited by

Synthesis, anticancer activity and molecular docking studies on a series of heterocyclic trans-cyanocombretastatin analogues as antitubulin agents.
Penthala NR, Zong H, Ketkar A, Madadi NR, Janganati V, Eoff RL, Guzman ML, Crooks PA. Penthala NR, et al. Eur J Med Chem. 2015 Mar 6;92:212-20. doi: 10.1016/j.ejmech.2014.12.050. Epub 2014 Dec 29. Eur J Med Chem. 2015. PMID: 25557492 Free PMC article.
Combretastatin A-4 derived imidazoles show cytotoxic, antivascular, and antimetastatic effects based on cytoskeletal reorganisation.
Mahal K, Biersack B, Caysa H, Schobert R, Mueller T. Mahal K, et al. Invest New Drugs. 2015 Jun;33(3):541-54. doi: 10.1007/s10637-015-0215-9. Epub 2015 Feb 14. Invest New Drugs. 2015. PMID: 25678082
Copper-Catalyzed Diboron-Mediated cis-Semi-Hydrogenation of Alkynes under Facile Conditions.
Zeng Y, Zhang H, Ma D, Wang G. Zeng Y, et al. Molecules. 2022 Oct 25;27(21):7213. doi: 10.3390/molecules27217213. Molecules. 2022. PMID: 36364041 Free PMC article.
Anticancer Activity of Thiophene Carboxamide Derivatives as CA-4 Biomimetics: Synthesis, Biological Potency, 3D Spheroid Model, and Molecular Dynamics Simulation.
Hawash M, Qaoud MT, Jaradat N, Abdallah S, Issa S, Adnan N, Hoshya M, Sobuh S, Hawash Z. Hawash M, et al. Biomimetics (Basel). 2022 Dec 17;7(4):247. doi: 10.3390/biomimetics7040247. Biomimetics (Basel). 2022. PMID: 36546947 Free PMC article.
Eco-friendly synthesis and antiproliferative evaluation of some oxygen substituted diaryl ketones.
Arenas P, Peña A, Ríos D, Benites J, Muccioli GG, Calderon PB, Valderrama JA. Arenas P, et al. Molecules. 2013 Aug 16;18(8):9818-32. doi: 10.3390/molecules18089818. Molecules. 2013. PMID: 23959193 Free PMC article.

See all "Cited by" articles

Publication types

Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions
Actions
Actions

LinkOut - more resources

Full Text Sources
- American Chemical Society
Other Literature Sources
- The Lens - Patent Citations Database