Glia-derived D-serine controls NMDA receptor activity and synaptic memory
- PMID: 16713567
- DOI: 10.1016/j.cell.2006.02.051
Glia-derived D-serine controls NMDA receptor activity and synaptic memory
Abstract
The NMDA receptor is a key player in excitatory transmission and synaptic plasticity in the central nervous system. Its activation requires the binding of both glutamate and a co-agonist like D-serine to its glycine site. As D-serine is released exclusively by astrocytes, we studied the physiological impact of the glial environment on NMDA receptor-dependent activity and plasticity. To this end, we took advantage of the changing astrocytic ensheathing of neurons occurring in the supraoptic nucleus during lactation. We provide direct evidence that in this hypothalamic structure the endogenous co-agonist of NMDA receptors is D-serine and not glycine. Consequently, the degree of astrocytic coverage of neurons governs the level of glycine site occupancy on the NMDA receptor, thereby affecting their availability for activation and thus the activity dependence of long-term synaptic changes. Such a contribution of astrocytes to synaptic metaplasticity fuels the emerging concept that astrocytes are dynamic partners of brain signaling.
Comment in
-
Astrocytes put down the broom and pick up the baton.Cell. 2006 May 19;125(4):639-41. doi: 10.1016/j.cell.2006.05.006. Cell. 2006. PMID: 16713554
Similar articles
-
Astrocytes put down the broom and pick up the baton.Cell. 2006 May 19;125(4):639-41. doi: 10.1016/j.cell.2006.05.006. Cell. 2006. PMID: 16713554
-
Regulation of N-methyl-D-aspartate receptors by astrocytic D-serine.Neuroscience. 2009 Jan 12;158(1):275-83. doi: 10.1016/j.neuroscience.2008.01.071. Epub 2008 Feb 19. Neuroscience. 2009. PMID: 18358625 Review.
-
D-serine regulation of NMDA receptor activity.Sci STKE. 2006 Oct 10;2006(356):pe41. doi: 10.1126/stke.3562006pe41. Sci STKE. 2006. PMID: 17033043 Review.
-
Potentiation of the NMDA receptor-mediated responses through the activation of the glycine site by microglia secreting soluble factors.Glia. 2006 Apr 15;53(6):660-8. doi: 10.1002/glia.20322. Glia. 2006. PMID: 16498631
-
Functional neuronal-glial anatomical remodelling in the hypothalamus.Novartis Found Symp. 2006;276:238-48; discussion 248-52, 275-81. Novartis Found Symp. 2006. PMID: 16805434 Review.
Cited by
-
Channel-mediated astrocytic glutamate release via Bestrophin-1 targets synaptic NMDARs.Mol Brain. 2013 Jan 16;6:4. doi: 10.1186/1756-6606-6-4. Mol Brain. 2013. PMID: 23324492 Free PMC article.
-
Conditional Astrocyte Rac1KO Attenuates Hyperreflexia after Spinal Cord Injury.J Neurosci. 2024 Jan 3;44(1):e1670222023. doi: 10.1523/JNEUROSCI.1670-22.2023. J Neurosci. 2024. PMID: 37963762 Free PMC article.
-
Multifunctional role of astrocytes as gatekeepers of neuronal energy supply.Front Cell Neurosci. 2013 Apr 10;7:38. doi: 10.3389/fncel.2013.00038. eCollection 2013. Front Cell Neurosci. 2013. PMID: 23596393 Free PMC article.
-
Protease activated receptor 1-induced glutamate release in cultured astrocytes is mediated by Bestrophin-1 channel but not by vesicular exocytosis.Mol Brain. 2012 Oct 12;5:38. doi: 10.1186/1756-6606-5-38. Mol Brain. 2012. PMID: 23062602 Free PMC article.
-
Astrocytes mediate in vivo cholinergic-induced synaptic plasticity.PLoS Biol. 2012 Feb;10(2):e1001259. doi: 10.1371/journal.pbio.1001259. Epub 2012 Feb 14. PLoS Biol. 2012. PMID: 22347811 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Research Materials
