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Comparative Study
. 2006 May;16(3):125-35.
doi: 10.2188/jea.16.125.

Dietary risk factors for colon and rectal cancers: a comparative case-control study

Kenji Wakai  1 , Kaoru Hirose, Keitaro Matsuo, Hidemi Ito, Kiyonori Kuriki, Takeshi Suzuki, Tomoyuki Kato, Takashi Hirai, Yukihide Kanemitsu, Kazuo Tajima
Affiliations
Comparative Study

Dietary risk factors for colon and rectal cancers: a comparative case-control study

Kenji Wakai et al. J Epidemiol. 2006 May.

Abstract

Background: In Japan, the incidence rate of colon cancer has more rapidly increased than that of rectal cancer. The differential secular trends may be due to different dietary factors in the development of colon and rectal cancers.

Methods: To compare dietary risk factors between colon and rectal cancers, we undertook a case-control study at Aichi Cancer Center Hospital, Japan. Subjects were 507 patients with newly diagnosed colon (n = 265) and rectal (n = 242) cancers, and 2,535 cancer-free outpatients (controls). Intakes of nutrients and food groups were assessed with a food frequency questionnaire, and multivariate-adjusted odds ratios (ORs) were estimated using unconditional logistic models.

Results: We found a decreasing risk of colon cancer with increasing intakes of calcium and insoluble dietary fiber; the multivariate ORs across quartiles of intake were 1.00, 0.90, 0.80, and 0.67 (trend p = 0.040), and 1.00, 0.69, 0.64, and 0.65 (trend p = 0.027), respectively. For rectal cancer, a higher consumption of carotene and meat was associated with a reduced risk; the corresponding ORs were 1.00, 1.10, 0.71, and 0.70 for carotene (trend p = 0.028), and 1.00, 0.99, 0.68, and 0.72 for meat (trend p = 0.036). Carbohydrate intake was positively correlated with the risk of rectal cancer (ORs over quartiles: 1.00, 1.14, 1.42, and 1.54; trend p = 0.048). This association was stronger in women, while fat consumption was inversely correlated with the risk of female colon and rectal cancers.

Conclusions: Dietary risk factors appear to considerably differ between colon and rectal cancers.

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References

    1. Ajiki W, Tsukuma H, Oshima A; for The Research Group for Population-based Cancer Registration in Japan . Cancer incidence and incidence rates in Japan in 1999: estimates based on data from 11 population-based cancer registries. Jpn J Clin Oncol 2004; 34: 352-6. - PubMed
    1. The Research Group for Population-based Cancer Registration in Japan. Cancer incidence in Japan. In: Tajima K, Kuroishi T, and Oshima A, eds. Cancer mortality and morbidity statistics. Japan Scientific Societies Press, Tokyo, 2004: 95-130.
    1. Parkin DM, Whelan SL, Ferlay J, Teppo L, Thomas DB. Cancer incidence in five continents, vol. 8. International Agency for Research on Cancer, Lyon, 2002.
    1. Lee HP, Gourley L, Duffy SW, Esteve J, Lee J, Day NE. Colorectal cancer and diet in an Asian population--a case-control study among Singapore Chinese. Int J Cancer 1989; 43: 1007-16. - PubMed
    1. Hu JF, Liu YY, Yu YK, Zhao TZ, Liu SD, Wang QQ. Diet and cancer of the colon and rectum: a case-control study in China. Int J Epidemiol 1991; 20: 362-7. - PubMed

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