Review
doi: 10.1016/j.bbamcr.2006.03.001.
Epub 2006 Mar 24.
Mitochondrial dynamics and aging: Mitochondrial interaction preventing individuals from expression of respiratory deficiency caused by mutant mtDNA
Affiliations
- PMID: 16624428
- DOI: 10.1016/j.bbamcr.2006.03.001
Item in Clipboard
Review
Mitochondrial dynamics and aging: Mitochondrial interaction preventing individuals from expression of respiratory deficiency caused by mutant mtDNA
Biochim Biophys Acta.
2006 May-Jun.
Free article
Abstract
In mammalian cells, there is an extensive and continuous exchange of mitochondrial DNA (mtDNA) and its products between mitochondria. This mitochondrial complementation prevents individuals from expression of respiration deficiency caused by mutant mtDNAs. Thus, the presence of mitochondrial complementation does not support the generally accepted mitochondrial theory of aging, which proposes that accumulation of somatic mutations in mtDNA is responsible for age-associated mitochondrial dysfunction. Moreover, the presence of mitochondrial complementation enables gene therapy for mitochondrial diseases using nuclear transplantation of zygotes.
Similar articles
-
Mitochondrial complementation preventing respiratory dysfunction caused by mutant mtDNA.Biofactors. 2009 Mar-Apr;35(2):130-7. doi: 10.1002/biof.14. Biofactors. 2009. PMID: 19449440 Review.
-
Mutations in mitochondrial DNA regulate mitochondrial diseases and metastasis but do not regulate aging.Curr Opin Genet Dev. 2016 Jun;38:63-67. doi: 10.1016/j.gde.2016.03.004. Epub 2016 Apr 11. Curr Opin Genet Dev. 2016. PMID: 27078865 Review.
-
Interaction theory of mammalian mitochondria.Biochem Biophys Res Commun. 2001 Nov 9;288(4):743-6. doi: 10.1006/bbrc.2001.5838. Biochem Biophys Res Commun. 2001. PMID: 11688969
-
Mosaic Deficiency in Mitochondrial Oxidative Metabolism Promotes Cardiac Arrhythmia during Aging.Cell Metab. 2015 May 5;21(5):667-77. doi: 10.1016/j.cmet.2015.04.005. Cell Metab. 2015. PMID: 25955204
-
Concise Review: Heteroplasmic Mitochondrial DNA Mutations and Mitochondrial Diseases: Toward iPSC-Based Disease Modeling, Drug Discovery, and Regenerative Therapeutics.Stem Cells. 2016 Apr;34(4):801-8. doi: 10.1002/stem.2292. Epub 2016 Feb 13. Stem Cells. 2016. PMID: 26850516 Review.
Cited by
-
Skeletal muscle mitochondria and aging: a review.J Aging Res. 2012;2012:194821. doi: 10.1155/2012/194821. Epub 2012 Jul 19. J Aging Res. 2012. PMID: 22888430 Free PMC article.
-
New insights into the role of mitochondria in aging: mitochondrial dynamics and more.J Cell Sci. 2010 Aug 1;123(Pt 15):2533-42. doi: 10.1242/jcs.070490. J Cell Sci. 2010. PMID: 20940129 Free PMC article. Review.
-
The mitochondrial DNA control region shows genetically correlated levels of heteroplasmy in leukocytes of centenarians and their offspring.BMC Genomics. 2007 Aug 29;8:293. doi: 10.1186/1471-2164-8-293. BMC Genomics. 2007. PMID: 17727699 Free PMC article.
-
Administration of Enalapril Started Late in Life Attenuates Hypertrophy and Oxidative Stress Burden, Increases Mitochondrial Mass, and Modulates Mitochondrial Quality Control Signaling in the Rat Heart.Biomolecules. 2018 Dec 17;8(4):177. doi: 10.3390/biom8040177. Biomolecules. 2018. PMID: 30563025 Free PMC article.
-
Mdm36 is a mitochondrial fission-promoting protein in Saccharomyces cerevisiae.Mol Biol Cell. 2010 Jul 15;21(14):2443-52. doi: 10.1091/mbc.e10-02-0096. Epub 2010 May 26. Mol Biol Cell. 2010. PMID: 20505073 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
