Decomposition of the linking number of a closed ribbon: A problem from molecular biology
- PMID: 16592550
- PMCID: PMC392823
- DOI: 10.1073/pnas.75.8.3557
Decomposition of the linking number of a closed ribbon: A problem from molecular biology
Abstract
A closed duplex DNA molecule relaxed and containing nucleosomes has a different linking number from the same molecule relaxed and without nucleosomes. What does this say about the structure of the nucleosome? A mathematical study of this question is made, representing the DNA molecule by a ribbon. It is shown that the linking number of a closed ribbon can be decomposed into the linking number of a reference ribbon plus a sum of locally determined "linking differences."
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