Review
doi: 10.4161/cc.5.5.2501.
Epub 2006 Mar 1.
Nutrient availability and growth: regulation of insulin signaling by dFOXO/FOXO1
Affiliations
- PMID: 16552183
- DOI: 10.4161/cc.5.5.2501
Item in Clipboard
Review
Nutrient availability and growth: regulation of insulin signaling by dFOXO/FOXO1
Cell Cycle.
2006 Mar.
Abstract
Organisms adjust their rate of growth depending on the availability of nutrients. Thus, when environmental conditions limit nutrients, growth is slowed and is only restored after food again becomes abundant. Many aspects of the molecular mechanisms that govern this complex control system remain unknown. However, it has been shown that the insulin/IGF-1 (insulin-like growth factor 1) receptor pathway, together with the FOXO family of transcription factors, play an important role in this process. Recent studies with the fruit fly Drosophila melanogaster have provided new insights into the regulatory circuitry that controls both growth and gene expression in response to nutrient availability.
Similar articles
-
Drosophila lifespan control by dietary restriction independent of insulin-like signaling.Aging Cell. 2008 Mar;7(2):199-206. doi: 10.1111/j.1474-9726.2008.00373.x. Epub 2008 Jan 21. Aging Cell. 2008. PMID: 18221413 Free PMC article.
-
Role of dFOXO in lifespan extension by dietary restriction in Drosophila melanogaster: not required, but its activity modulates the response.Aging Cell. 2008 Mar;7(2):187-98. doi: 10.1111/j.1474-9726.2007.00362.x. Epub 2008 Jan 30. Aging Cell. 2008. PMID: 18241326
-
Understanding Forkhead box class O function: lessons from Drosophila melanogaster.Antioxid Redox Signal. 2011 Feb 15;14(4):635-47. doi: 10.1089/ars.2010.3407. Epub 2010 Oct 20. Antioxid Redox Signal. 2011. PMID: 20618068 Review.
-
Drosophila FoxO regulates organism size and stress resistance through an adenylate cyclase.Mol Cell Biol. 2009 Oct;29(19):5357-65. doi: 10.1128/MCB.00302-09. Epub 2009 Aug 3. Mol Cell Biol. 2009. PMID: 19651894 Free PMC article.
-
The role of insulin signalling in the endocrine stress response in Drosophila melanogaster: A mini-review.Gen Comp Endocrinol. 2018 Mar 1;258:134-139. doi: 10.1016/j.ygcen.2017.05.019. Epub 2017 May 26. Gen Comp Endocrinol. 2018. PMID: 28554733 Review.
Cited by
-
Tools for investigating O-GlcNAc in signaling and other fundamental biological pathways.J Biol Chem. 2024 Feb;300(2):105615. doi: 10.1016/j.jbc.2023.105615. Epub 2023 Dec 29. J Biol Chem. 2024. PMID: 38159850 Free PMC article. Review.
-
Kinetics of nuclear-cytoplasmic translocation of Foxo1 and Foxo3A in adult skeletal muscle fibers.Am J Physiol Cell Physiol. 2012 Nov 1;303(9):C977-90. doi: 10.1152/ajpcell.00027.2012. Epub 2012 Aug 29. Am J Physiol Cell Physiol. 2012. PMID: 22932683 Free PMC article.
-
O-GlcNAc regulates FoxO activation in response to glucose.J Biol Chem. 2008 Jun 13;283(24):16283-92. doi: 10.1074/jbc.M802240200. Epub 2008 Apr 17. J Biol Chem. 2008. PMID: 18420577 Free PMC article.
-
CD36-dependent regulation of muscle FoxO1 and PDK4 in the PPAR delta/beta-mediated adaptation to metabolic stress.J Biol Chem. 2008 May 23;283(21):14317-26. doi: 10.1074/jbc.M706478200. Epub 2008 Feb 28. J Biol Chem. 2008. PMID: 18308721 Free PMC article.
-
The sleeping beauty: how reproductive diapause affects hormone signaling, metabolism, immune response and somatic maintenance in Drosophila melanogaster.PLoS One. 2014 Nov 13;9(11):e113051. doi: 10.1371/journal.pone.0113051. eCollection 2014. PLoS One. 2014. PMID: 25393614 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Molecular Biology Databases
Research Materials
Miscellaneous
