Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4
- PMID: 16543935
- DOI: 10.1038/sj.cdd.4401912
Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4
Similar articles
-
Mdm4 and Mdm2 cooperate to inhibit p53 activity in proliferating and quiescent cells in vivo.Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3232-7. doi: 10.1073/pnas.0508476103. Epub 2006 Feb 21. Proc Natl Acad Sci U S A. 2006. PMID: 16492744 Free PMC article.
-
Synergistic roles of Mdm2 and Mdm4 for p53 inhibition in central nervous system development.Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3226-31. doi: 10.1073/pnas.0508500103. Epub 2006 Feb 21. Proc Natl Acad Sci U S A. 2006. PMID: 16492743 Free PMC article.
-
Regulating the p53 pathway: in vitro hypotheses, in vivo veritas.Nat Rev Cancer. 2006 Dec;6(12):909-23. doi: 10.1038/nrc2012. Nat Rev Cancer. 2006. PMID: 17128209 Review.
-
A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network.Cancer Cell. 2006 Apr;9(4):273-85. doi: 10.1016/j.ccr.2006.03.014. Cancer Cell. 2006. PMID: 16616333
-
Mouse models of Mdm2 and Mdm4 and their clinical implications.Chin J Cancer. 2013 Jul;32(7):371-5. doi: 10.5732/cjc.012.10286. Epub 2013 Jan 18. Chin J Cancer. 2013. PMID: 23327795 Free PMC article. Review.
Cited by
-
The p53--Mdm2--HAUSP complex is involved in p53 stabilization by HAUSP.Oncogene. 2007 Nov 8;26(51):7262-6. doi: 10.1038/sj.onc.1210531. Epub 2007 May 21. Oncogene. 2007. PMID: 17525743 Free PMC article.
-
The Mdm2-p53 relationship evolves: Mdm2 swings both ways as an oncogene and a tumor suppressor.Genes Dev. 2010 Aug 1;24(15):1580-9. doi: 10.1101/gad.1941710. Genes Dev. 2010. PMID: 20679392 Free PMC article. Review.
-
A genetic variant within MDM4 3'UTR miRNA binding site is associated with HPV16-positive tumors and survival of oropharyngeal cancer.Mol Carcinog. 2019 Dec;58(12):2276-2285. doi: 10.1002/mc.23116. Epub 2019 Sep 12. Mol Carcinog. 2019. PMID: 31513313 Free PMC article.
-
Mdm2 is required for survival of hematopoietic stem cells/progenitors via dampening of ROS-induced p53 activity.Cell Stem Cell. 2010 Nov 5;7(5):606-17. doi: 10.1016/j.stem.2010.09.013. Cell Stem Cell. 2010. PMID: 21040902 Free PMC article.
-
Enigma negatively regulates p53 through MDM2 and promotes tumor cell survival in mice.J Clin Invest. 2010 Dec;120(12):4493-506. doi: 10.1172/JCI42674. Epub 2010 Nov 8. J Clin Invest. 2010. PMID: 21060154 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Molecular Biology Databases
Research Materials
Miscellaneous