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Review
. 2006 Apr;80(7):3128-34.
doi: 10.1128/JVI.80.7.3128-3134.2006.

Toll-like receptor-independent triggering of dendritic cell maturation by viruses

Carolina B López  1 , Jacob S Yount, Thomas M Moran
Affiliations
Review

Toll-like receptor-independent triggering of dendritic cell maturation by viruses

Carolina B López et al. J Virol. 2006 Apr.
No abstract available

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Figures

FIG. 1.
FIG. 1.
TLR-independent pathway for DC maturation by viruses.
FIG. 2.
FIG. 2.
Model for cDC maturation upon virus infection. Virus infection triggers induction of both type I IFN and DC maturation through the activation of transcription factors, such as IRF3 and NF-κB. DC maturation is characterized by the up-regulation of major histocompatibility complex and costimulatory molecules and by the secretion of proinflammatory cytokines, such as IL-12. Complete maturation of cDCs in response to virus does not rely on secreted type I IFN or TLR signaling. Nevertheless, the concomitant activation of the type I IFN induction pathway and DC maturation pathway suggests that dsRNA-binding molecules known to be involved in type I IFN induction, such as RIG-I or mda-5, may also lead to DC maturation, while the dsRNA-binding protein PKR has been shown to be unnecessary for complete DC maturation in response to live viruses. Signaling pathways shown in gray are dispensable for complete DC maturation.
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