Bioenergetic aspects of apoptosis, necrosis and mitoptosis
- PMID: 16532373
- DOI: 10.1007/s10495-006-5881-9
Bioenergetic aspects of apoptosis, necrosis and mitoptosis
Abstract
In this review I summarize interrelations between bioenergetic processes and such programmed death phenomena as cell suicide (apoptosis and necrosis) and mitochondrial suicide (mitoptosis). The following conclusions are made. (I) ATP and rather often mitochondrial hyperpolarization (i.e. an increase in membrane potential, delta psi) are required for certain steps of apoptosis and necrosis. (II) Apoptosis, even if it is accompanied by delta psi and [ATP] increases at its early stage, finally results in a delta psi collapse and ATP decrease. (III) Moderate (about three-fold) lowering of [ATP] for short and long periods of time induces apoptosis and necrosis, respectively. In some types of apoptosis and necrosis, the cell death is mediated by a delta psi-dependent overproduction of ROS by the initial (Complex I) and the middle (Complex III) spans of the respiratory chain. ROS initiate mitoptosis which is postulated to rid the intracellular population of mitochondria from those that are ROS overproducing. Massive mitoptosis can result in cell death due to release to cytosol of the cell death proteins normally hidden in the mitochondrial intermembrane space.
Similar articles
-
Mitochondria in the programmed death phenomena; a principle of biology: "it is better to die than to be wrong".IUBMB Life. 2000 May;49(5):365-73. doi: 10.1080/152165400410209. IUBMB Life. 2000. PMID: 10902567 Review.
-
Mitochondrial complex I defect induces ROS release and degeneration in trabecular meshwork cells of POAG patients: protection by antioxidants.Invest Ophthalmol Vis Sci. 2008 Apr;49(4):1447-58. doi: 10.1167/iovs.07-1361. Invest Ophthalmol Vis Sci. 2008. PMID: 18385062
-
Ceramide-induced formation of ROS and ATP depletion trigger necrosis in lymphoid cells.Free Radic Biol Med. 2008 Mar 15;44(6):1146-60. doi: 10.1016/j.freeradbiomed.2007.12.017. Epub 2007 Dec 23. Free Radic Biol Med. 2008. PMID: 18191646
-
Mitochondrial alterations related to programmed cell death in tobacco cells under aluminium stress.C R Biol. 2008 Aug;331(8):597-610. doi: 10.1016/j.crvi.2008.04.008. Epub 2008 Jun 2. C R Biol. 2008. PMID: 18606389
-
New control of mitochondrial membrane potential and ROS formation--a hypothesis.Biol Chem. 2001 Dec;382(12):1629-36. doi: 10.1515/BC.2001.198. Biol Chem. 2001. PMID: 11843176 Review.
Cited by
-
Apoptosis induction of human bladder cancer cells by sanguinarine through reactive oxygen species-mediated up-regulation of early growth response gene-1.PLoS One. 2013 May 22;8(5):e63425. doi: 10.1371/journal.pone.0063425. Print 2013. PLoS One. 2013. PMID: 23717422 Free PMC article.
-
Interconnections between apoptotic, autophagic and necrotic pathways: implications for cancer therapy development.J Cell Mol Med. 2013 Jan;17(1):12-29. doi: 10.1111/jcmm.12001. Epub 2013 Jan 10. J Cell Mol Med. 2013. PMID: 23301705 Free PMC article. Review.
-
Atmospheric-pressure plasma jet induces apoptosis involving mitochondria via generation of free radicals.PLoS One. 2011;6(11):e28154. doi: 10.1371/journal.pone.0028154. Epub 2011 Nov 29. PLoS One. 2011. PMID: 22140530 Free PMC article.
-
Acinetobacter baumannii outer membrane protein A induces dendritic cell death through mitochondrial targeting.J Microbiol. 2010 Jun;48(3):387-92. doi: 10.1007/s12275-010-0155-1. Epub 2010 Jun 23. J Microbiol. 2010. PMID: 20571958
-
Secondary necrosis in multicellular animals: an outcome of apoptosis with pathogenic implications.Apoptosis. 2008 Apr;13(4):463-82. doi: 10.1007/s10495-008-0187-8. Epub 2008 Mar 6. Apoptosis. 2008. PMID: 18322800 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
