Impact of quorum sensing on fitness of Pseudomonas aeruginosa
- PMID: 16503417
- DOI: 10.1016/j.ijmm.2006.01.043
Impact of quorum sensing on fitness of Pseudomonas aeruginosa
Abstract
In Pseudomonas aeruginosa, cell-cell communication based on N-acyl-homoserine lactone (AHL) signal molecules (termed quorum sensing) is known to control the production of extracellular virulence factors. Hence, in pathogenic interactions with host organisms, the quorum-sensing (QS) machinery can confer a selective advantage on P. aeruginosa. However, as shown by transcriptomic and proteomic studies, many intracellular metabolic functions are also regulated by quorum sensing. Some of these serve to regenerate the AHL precursors methionine and S-adenosyl-methionine and to degrade adenosine via inosine and hypoxanthine. The fact that a significant percentage of clinical and environmental isolates of P. aeruginosa is defective for QS because of mutation in the major QS regulatory gene lasR, raises the question of whether the QS machinery can have a negative impact on the organism's fitness. In vitro, lasR mutants have a higher probability to escape lytic death in stationary phase under alkaline conditions than has the QS-proficient wild type. Similar selective forces might also operate in natural environments.
Similar articles
-
Analysis of quorum sensing-dependent virulence factor production and its relationship with antimicrobial susceptibility in Pseudomonas aeruginosa respiratory isolates.Clin Microbiol Infect. 2010 Dec;16(12):1770-5. doi: 10.1111/j.1469-0691.2010.03177.x. Clin Microbiol Infect. 2010. PMID: 20132256
-
Characterization of N-butanoyl-L-homoserine lactone (C4-HSL) deficient clinical isolates of Pseudomonas aeruginosa.Microb Pathog. 2008 Jan;44(1):13-9. doi: 10.1016/j.micpath.2007.06.005. Epub 2007 Jul 4. Microb Pathog. 2008. PMID: 17689222
-
The contribution of MvfR to Pseudomonas aeruginosa pathogenesis and quorum sensing circuitry regulation: multiple quorum sensing-regulated genes are modulated without affecting lasRI, rhlRI or the production of N-acyl-L-homoserine lactones.Mol Microbiol. 2005 Feb;55(4):998-1014. doi: 10.1111/j.1365-2958.2004.04448.x. Mol Microbiol. 2005. PMID: 15686549
-
Quorum-sensing inhibitors as anti-pathogenic drugs.Int J Med Microbiol. 2006 Apr;296(2-3):149-61. doi: 10.1016/j.ijmm.2006.02.005. Epub 2006 Feb 28. Int J Med Microbiol. 2006. PMID: 16503194 Review.
-
[Quorum sensing in Pseudomonas aeruginosa: cell to-cell communication to sense the cell density of the same species].Tanpakushitsu Kakusan Koso. 2003 Aug;48(11 Suppl):1609-15. Tanpakushitsu Kakusan Koso. 2003. PMID: 12931620 Review. Japanese. No abstract available.
Cited by
-
Instantaneous within-patient diversity of Pseudomonas aeruginosa quorum-sensing populations from cystic fibrosis lung infections.Infect Immun. 2009 Dec;77(12):5631-9. doi: 10.1128/IAI.00755-09. Epub 2009 Oct 5. Infect Immun. 2009. PMID: 19805523 Free PMC article.
-
Quorum Sensing Is Accompanied by Global Metabolic Changes in the Opportunistic Human Pathogen Pseudomonas aeruginosa.J Bacteriol. 2015 Jun 15;197(12):2072-82. doi: 10.1128/JB.02557-14. Epub 2015 Apr 13. J Bacteriol. 2015. PMID: 25868647 Free PMC article.
-
The Evolution of Quorum Sensing as a Mechanism to Infer Kinship.PLoS Comput Biol. 2016 Apr 27;12(4):e1004848. doi: 10.1371/journal.pcbi.1004848. eCollection 2016 Apr. PLoS Comput Biol. 2016. PMID: 27120081 Free PMC article.
-
Multiple roles of Pseudomonas aeruginosa TBCF10839 PilY1 in motility, transport and infection.Mol Microbiol. 2009 Feb;71(3):730-47. doi: 10.1111/j.1365-2958.2008.06559.x. Epub 2008 Dec 1. Mol Microbiol. 2009. PMID: 19054330 Free PMC article.
-
Regulatory and metabolic networks for the adaptation of Pseudomonas aeruginosa biofilms to urinary tract-like conditions.PLoS One. 2013 Aug 13;8(8):e71845. doi: 10.1371/journal.pone.0071845. eCollection 2013. PLoS One. 2013. PMID: 23967252 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
