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. 2006 Mar;80(6):3122-5.
doi: 10.1128/JVI.80.6.3122-3125.2006.

Relative dominance of Gag p24-specific cytotoxic T lymphocytes is associated with human immunodeficiency virus control

Rosario Zuñiga  1 , Aldo Lucchetti, Patricia Galvan, Shyla Sanchez, Carmen Sanchez, Ana Hernandez, Hugo Sanchez, Nicole Frahm, Caitlyn H Linde, Hannah S Hewitt, William Hildebrand, Marcus Altfeld, Todd M Allen, Bruce D Walker, Bette T Korber, Thomas Leitner, Jorge Sanchez, Christian Brander
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Relative dominance of Gag p24-specific cytotoxic T lymphocytes is associated with human immunodeficiency virus control

Rosario Zuñiga et al. J Virol. 2006 Mar.

Abstract

Conflicting data on the role of total virus- and protein-specific cytotoxic-T-lymphocyte (CTL) responses in the control of human immunodeficiency virus (HIV) disease progression exist. We present data generated from a Peruvian cohort of untreated, clade B-infected subjects, demonstrating that the proportion of Gag-specific, and in particular p24-reactive, CTL responses among the total virus-specific CTL activity is associated with individuals' CD4 counts and viral loads. Analyses in a second cohort in the United States confirm these findings and point towards a dominant role of Gag-specific immunity in effective control of HIV infection, providing important guidance for HIV vaccine development.

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Figures

FIG. 1.
FIG. 1.
CTL responses are distributed over the entire HIV genome and cluster in immunodominant regions. A total of 45 Peruvian subjects were tested for their total HIV-specific CD8+ T-cell activity by using an overlapping peptide set of 410 peptides. The figure shows the frequency of recognition for each single peptide among the 45 subjects tested (y axis). The horizontal box indicates the HIV proteins spanned by the overlapping peptides.
FIG. 2.
FIG. 2.
Relative Gag-specific magnitude and breadth are associated with increased CD4 T-cell counts; ELISpot data from 45 untreated and chronically infected subjects were recorded as breadth (number of OLP targeted) or magnitude (SFC/106 PBMC) of responses and compared to individuals' CD4 counts. Responses were calculated either for the total virus-specific response (A and C) or the relative proportion of the Gag-specific activity only (B and D). P values are based on Spearman's rank test (two-sided) and are shown before correction for multiple comparisons.
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