Review
Diamidines as antitrypanosomal, antileishmanial and antimalarial agents
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Review
Diamidines as antitrypanosomal, antileishmanial and antimalarial agents
Curr Opin Investig Drugs.
2006 Feb.
Abstract
Diamidine-containing compounds have a long history of use in the treatment of African trypanosomiasis and leishmaniasis. The discovery that diamidine prodrugs possess in vivo antimicrobial activity when administered orally has led to a renewed interest in this class of compounds for the treatment of parasitic infections. In this review, the selectivity of diamidines against trypanosomes, Leishmania and Plasmodium is rationalized through mechanism-of-action studies. An overview of the antiprotozoal activities of newer diamidines and diamidine prodrugs is also presented, along with a summary of the progress made toward the clinical development of new diamidines for use against these parasitic diseases.
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