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Comparative Study
. 2006 Feb;46(2):197-9.
doi: 10.1111/j.1526-4610.2006.00330.x.

C-reactive protein may be increased in migraine patients who present with complex clinical features

K M A Welch  1 , Avery W Brandes, Lauren Salerno, Jan Lewis Brandes
Affiliations
Comparative Study

C-reactive protein may be increased in migraine patients who present with complex clinical features

K M A Welch et al. Headache. 2006 Feb.

Abstract

Objectives: Stroke risk is increased in migraine, the basis of which remains to be established. C-reactive protein (CRP) is a marker of cerebrovascular disease, suggesting in part an inflammatory mechanism. Because attacks of migraine may involve repeated sterile vascular inflammation, we measured CRP in migraine patients.

Methods: Retrospective review was conducted of 60 randomly sampled charts of patients with the diagnosis of migraine without aura (MwoA, n = 29) and migraine with aura (MwA, n = 31), in which CRP was recorded as part of the differential diagnostic evaluation. CRP was measured by standard commercial laboratory methods; high sensitivity CRP (hs-CRP) values above 3mg/L were considered abnormal.

Results: Elevated hs-CRP was found in 43% of all patients (26 of 60). In MwoA, of 29 subjects, abnormal hs-CRP was recorded in 16; in 10 no other conditions were found to explain the abnormality. In MwA, of 31 subjects, abnormal CRP was recorded in 10; in 5 no other condition could explain the abnormality. No associations were found between other demographic or clinical features.

Conclusions: CRP may be abnormal in MwoA and MwA patients who present with atypical, severe, or complex clinical features that require extensive differential diagnostic investigation.

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