Telomere length in small-for-gestational-age babies
- PMID: 16487204
- DOI: 10.1111/j.1471-0528.2005.00839.x
Telomere length in small-for-gestational-age babies
Abstract
Objective: Short telomeres are associated with adult cardiovascular disease. Our aim was to determine whether small-for-gestational-age (SGA) newborns have shortened telomeres compared with appropriately grown controls.
Design: Prospective cohort study.
Setting: Large tertiary referral unit in Trent, UK.
Population: Seventy-two women who delivered at 35-42 weeks of gestation were recruited; 34 delivered SGA babies (less than or equal to the third birthweight centile) and 38 had appropriately grown babies (greater than the tenth centile).
Methods: Maternal and cord blood samples were collected at delivery. A Southern blot of DNA from these samples was hybridised with a 32P-labelled telomeric probe and telomere length was measured.
Main outcome measures: Mean maternal and newborn telomere length.
Results: Maternal and newborn telomere lengths were significantly correlated in both the SGA and the control groups (r2 = 0.25, P < 0.0001). Telomere lengths were similar in both maternal (control 8.41 +/- 0.9 kb versus SGA 8.29 +/- 1.0 kb, P = 0.57) and newborn (control 10.36 +/- 1.5 kb versus SGA 10.33 +/- 1.3 kb, P = 0.93) cohorts in the two groups.
Conclusions: Intrauterine events associated with impaired fetal growth do not appear to be associated with increased telomere shortening.
Similar articles
-
Customized birthweight centiles predict SGA pregnancies with perinatal morbidity.BJOG. 2005 Aug;112(8):1026-33. doi: 10.1111/j.1471-0528.2005.00656.x. BJOG. 2005. PMID: 16045513
-
Should parity be included in customised fetal weight standards for identifying small-for-gestational-age babies? Results from a French multicentre study.BJOG. 2008 Sep;115(10):1256-64. doi: 10.1111/j.1471-0528.2008.01855.x. BJOG. 2008. PMID: 18715411
-
Maternal sleep deprivation is a risk factor for small for gestational age: a cohort study.Aust N Z J Obstet Gynaecol. 2009 Aug;49(4):382-7. doi: 10.1111/j.1479-828X.2009.01010.x. Aust N Z J Obstet Gynaecol. 2009. PMID: 19694692
-
Long-term effects of intrauterine growth retardation.Acta Paediatr Suppl. 1997 Jul;422:83-4. doi: 10.1111/j.1651-2227.1997.tb18352.x. Acta Paediatr Suppl. 1997. PMID: 9298800 Review.
-
The longer your telomeres, the larger your nevus?Am J Dermatopathol. 2003 Feb;25(1):83-4. Am J Dermatopathol. 2003. PMID: 12544108 Review. No abstract available.
Cited by
-
Preterm Birth and Its Association with Maternal Diet, and Placental and Neonatal Telomere Length.Nutrients. 2023 Nov 30;15(23):4975. doi: 10.3390/nu15234975. Nutrients. 2023. PMID: 38068836 Free PMC article. Review.
-
Mice transgenic with SV40-late-promoter-driven Polyomavirus Middle T oncogene exclusively develop hemangiomas.Transgenic Res. 2009 Jun;18(3):399-406. doi: 10.1007/s11248-008-9232-1. Epub 2008 Dec 9. Transgenic Res. 2009. PMID: 19067215
-
Prenatal programming-effects on blood pressure and renal function.Nat Rev Nephrol. 2011 Mar;7(3):137-44. doi: 10.1038/nrneph.2011.1. Epub 2011 Feb 1. Nat Rev Nephrol. 2011. PMID: 21283139 Review.
-
Can telomere shortening be the main indicator of non-viable fetus elimination?Mol Cytogenet. 2018 Jan 25;11:11. doi: 10.1186/s13039-018-0361-9. eCollection 2018. Mol Cytogenet. 2018. PMID: 29416566 Free PMC article.
-
Leukocyte telomere length and carotid artery intimal medial thickness: the Framingham Heart Study.Arterioscler Thromb Vasc Biol. 2008 Jun;28(6):1165-71. doi: 10.1161/ATVBAHA.107.154849. Epub 2008 Apr 3. Arterioscler Thromb Vasc Biol. 2008. PMID: 18388332 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
