A network of networks: quorum-sensing gene regulation in Pseudomonas aeruginosa
- PMID: 16476569
- DOI: 10.1016/j.ijmm.2006.01.036
A network of networks: quorum-sensing gene regulation in Pseudomonas aeruginosa
Abstract
The opportunistic pathogen Pseudomonas aeruginosa possesses two N-acyl-homoserine lactone quorum-sensing systems that regulate large, overlapping sets of genes. Recent global transcriptome and proteome analyses provided a wealth of information about the identity of the regulated genes, N-acyl-homoserine lactone signal specificity, timing of induction, and environmental effects on gene expression. Quorum-sensing gene expression in P. aeruginosa is also embedded in a highly interconnected network of other regulatory systems with a high potential for integrating and responding to multiple environmental signals. Such epigenetic complexity may constitute the basis for the exceptional adaptability of P. aeruginosa to diverse environments.
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