Organization of intracellular calcium signals generated by inositol lipid-dependent hormones
- PMID: 1647036
- DOI: 10.1016/0163-7258(91)90056-r
Organization of intracellular calcium signals generated by inositol lipid-dependent hormones
Abstract
Recent studies at the single cell level have demonstrated hitherto unsuspected complexities in the organization of intracellular Ca2+ homeostasis in both the temporal and spatial domains. Activation of receptors coupled to the phosphoinositide signalling system has been shown to generate [Ca2+]i oscillations in many cell types. These oscillations display diverse patterns, with variations in oscillation amplitude, latency and frequency which are often tissue and/or agonist dose specific. Furthermore, increases in [Ca2+]i can either occur uniformly or originate from a specific region and propagate throughout the cell in the form of a Ca2+ wave. The significance and underlying mechanisms responsible for these phenomena are discussed.
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