Review
doi: 10.1016/j.it.2006.01.005.
Epub 2006 Feb 3.
The dichotomous role of IL-2: tolerance versus immunity
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- PMID: 16459146
- DOI: 10.1016/j.it.2006.01.005
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Review
The dichotomous role of IL-2: tolerance versus immunity
Trends Immunol.
2006 Mar.
Abstract
Interleukin-2 (IL-2) is a well-known T-cell growth factor, which is traditionally implicated in the agonistic stimulation of immune responses. Recent work, however, has uncovered an unexpected function of this cytokine. In particular, IL-2 appears crucial to maintaining peripheral tolerance by supporting the survival and function of CD25+ CD4+ regulatory T cells. A recent study examining the role of IL-2 in the peripheral generation of regulatory T cells from apparently naïve T cells has gone some way to reconciling the seemingly opposing functions of this cytokine.
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