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. 2006 Feb;143(2):373-9.
doi: 10.1111/j.1365-2249.2006.02999.x.

Age dependency and mutual relations in T and B lymphocyte abnormalities in common variable immunodeficiency patients

M Vlková  1 , V Thon, M Sárfyová, L Bláha, A Svobodník, J Lokaj, J Litzman
Affiliations

Age dependency and mutual relations in T and B lymphocyte abnormalities in common variable immunodeficiency patients

M Vlková et al. Clin Exp Immunol. 2006 Feb.

Abstract

Common variable immunodeficiency (CVID) is primary hypogammaglobulinaemia with an unknown aetiopathogenesis. Although various abnormalities of T and B cells have been described, their pathogenetic roles are unclear. We determined T and B lymphocyte subsets known to be abnormal in CVID in order to disclose possible relations between numerical abnormalities in those cells. Markers associated with B cell development (CD21, CD27, IgM, IgD) were determined on B lymphocytes (CD19+); T lymphocyte development (CD45RA, CD45RO, CD62L) and activation markers (CD25, CD27, CD28, CD29, CD38, CD57, HLA-DR) were determined on CD4+ and CD8+ T lymphocytes in 42 CVID patients and in 33 healthy controls. Abnormalities in CD4+ T lymphocyte activation markers (increase in CD29, HLA-DR, CD45RO, decrease in CD27, CD62L, CD45RA) were observed particularly in patients with a decreased number of memory (CD27+) and mature (CD21+) B cells (group Ia according to the Freiburg group's classification), while abnormalities observed in CD8+ cells (increase in CD27 and CD28 and decrease in HLA-DR, CD57 and CD38) did not depend upon grouping patients together according to B lymphocyte developmental subpopulations. We observed correlations between immature B cells (IgM+ CD21-) and expression of CD27, CD62L, CD45RA, CD45RO and HLA-DR on CD4+ T cells in CVID patients but not in the control group. The expression of CD27 and CD45RA on CD4+ T lymphocytes, such as the percentage of IgD+ CD27- and IgD+ CD27+ cells in B lymphocytes, showed age dependency to be more significant than in the control group. Our study demonstrates that T and B lymphocyte abnormalities in CVID are partially related to each other. Some of those abnormalities are not definite, but may evolve with age of the patient.

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Figures

Fig. 1
Fig. 1
Age distribution in common variable immunodeficiency subgroups.
Fig. 2
Fig. 2
Plots of significant correlations between age and evaluated lymphocyte subpopulations in common variable immunodeficiency patients. Spearman's rank correlation (R) was used. Using Bonferroni's correction only values of P < 0·002 were considered to be significant. No significant correlations were observed for all antigens expressed on CD8+ cells and for CD4+ cells expressing markers CD28, CD29, CD62L CD25 and HLA-DR. The only positive correlation observed in the control group was between the age and percentage of CD45RO+ CD4+/CD4+. Using Bonferroni's correction only values of P < 0·0001 were considered to be significant for the control group.
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