Review
doi: 10.1016/j.yexcr.2005.11.028.
Epub 2006 Jan 9.
p63 and epithelial biology
Affiliations
- PMID: 16406339
- DOI: 10.1016/j.yexcr.2005.11.028
Item in Clipboard
Review
p63 and epithelial biology
Exp Cell Res.
.
Abstract
The transcription factor p63 is a homologue of the tumor suppressor p53. Unlike p53, which is dispensable for normal development, p63 is critical for the development of stratified epithelial tissues such as epidermis, breast, and prostate. p63 encodes multiple protein isoforms with both transactivating and transcriptional repressor activities that can regulate a wide spectrum of target genes. p63 is also implicated in tumor formation and progression in stratified epithelia, with evidence for both tumor suppressive and oncogenic properties. This review will examine current data and hypotheses regarding the role of p63 in the development, maintenance, and tumorigenesis of stratified epithelium.
Similar articles
-
p63: Molecular complexity in development and cancer.Carcinogenesis. 2004 Jun;25(6):857-64. doi: 10.1093/carcin/bgh148. Epub 2004 Mar 19. Carcinogenesis. 2004. PMID: 15033906 Review.
-
p63 and epithelial appendage development.Differentiation. 2004 Oct;72(8):364-70. doi: 10.1111/j.1432-0436.2004.07208002.x. Differentiation. 2004. PMID: 15606495 Review.
-
TA-p63-gamma regulates expression of DeltaN-p63 in a manner that is sensitive to p53.Oncogene. 2006 Apr 13;25(16):2349-59. doi: 10.1038/sj.onc.1209270. Oncogene. 2006. PMID: 16331262
-
Loss of p63 leads to increased cell migration and up-regulation of genes involved in invasion and metastasis.Cancer Res. 2006 Aug 1;66(15):7589-97. doi: 10.1158/0008-5472.CAN-06-2020. Cancer Res. 2006. PMID: 16885358
-
p63 expression is associated with p53 loss in oral-esophageal epithelia of p53-deficient mice.Cancer Res. 2001 Sep 1;61(17):6467-73. Cancer Res. 2001. PMID: 11522642
Cited by
-
Repression of p63 and induction of EMT by mutant Ras in mammary epithelial cells.Proc Natl Acad Sci U S A. 2016 Oct 11;113(41):E6107-E6116. doi: 10.1073/pnas.1613417113. Epub 2016 Sep 28. Proc Natl Acad Sci U S A. 2016. PMID: 27681615 Free PMC article.
-
Regulation of Notch1 gene expression by p53 in epithelial cells.Mol Cell Biol. 2007 May;27(10):3732-42. doi: 10.1128/MCB.02119-06. Epub 2007 Mar 12. Mol Cell Biol. 2007. PMID: 17353266 Free PMC article.
-
Altered expression of cell-cell adhesion molecules β-catenin/E-cadherin and related Wnt-signaling pathway in sporadic and syndromal keratocystic odontogenic tumors.Clin Oral Investig. 2011 Jun;15(3):321-8. doi: 10.1007/s00784-010-0388-8. Epub 2010 Feb 27. Clin Oral Investig. 2011. PMID: 20195877
-
Increased invasiveness and aggressiveness in breast epithelia with cytoplasmic p63 expression.Int J Biol Sci. 2010 Aug 8;6(5):428-42. doi: 10.7150/ijbs.6.428. Int J Biol Sci. 2010. PMID: 20714441 Free PMC article.
-
p63 short isoforms are found in invasive carcinomas only and not in benign breast conditions.Virchows Arch. 2010 Apr;456(4):395-401. doi: 10.1007/s00428-010-0900-1. Epub 2010 Mar 12. Virchows Arch. 2010. PMID: 20225093
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Research Materials
Miscellaneous
