The beta globin gene cluster of the prosimian primate Galago crassicaudatus: nucleotide sequence determination of the 41-kb cluster and comparative sequence analyses
- PMID: 1639402
- DOI: 10.1016/0888-7543(92)90150-q
The beta globin gene cluster of the prosimian primate Galago crassicaudatus: nucleotide sequence determination of the 41-kb cluster and comparative sequence analyses
Abstract
The nucleotide sequence of the beta globin gene cluster of the prosimian Galago crassicaudatus has been determined. A total sequence spanning 41,101 bp contains and links together previously published sequences of the five galago beta-like globin genes (5'-epsilon-gamma-psi eta-delta-beta-3'). A computer-aided search for middle interspersed repetitive sequences identified 10 LINE (L1) elements, including a 5' truncated repeat that is orthologous to the full-length L1 element found in the human epsilon-gamma intergenic region. SINE elements that were identified included one Alu type I repeat, four Alu type II repeats, and two methionine tRNA-derived Monomer (type III) elements. Alu type II and Monomer sequences are unique to the galago genome. Structural analyses of the cluster sequence reveals that it is relatively A+T rich (about 62%) and regions with high G+C content are associated primarily with globin coding regions. Comparative analyses with the beta globin cluster sequences of human, rabbit, and mouse reveal extensive sequence homologies in their genic regions, but only human, galago, and rabbit sequences share extensive intergenic sequence homologies. Divergence analyses of aligned intergenic and flanking sequences from orthologous human, galago, and rabbit sequences show a gradation in the rate of nucleotide sequence evolution along the cluster where sequences 5' of the epsilon globin gene region show the least sequence divergence and sequences just 5' of the beta globin gene region show the greatest sequence divergence.
Similar articles
-
Complete nucleotide sequence of the rabbit beta-like globin gene cluster. Analysis of intergenic sequences and comparison with the human beta-like globin gene cluster.J Mol Biol. 1989 Jan 5;205(1):15-40. doi: 10.1016/0022-2836(89)90362-8. J Mol Biol. 1989. PMID: 2486295
-
Primate evolution of the alpha-globin gene cluster and its Alu-like repeats.J Mol Biol. 1986 Dec 20;192(4):693-709. doi: 10.1016/0022-2836(86)90022-7. J Mol Biol. 1986. PMID: 3586010
-
Sequence and comparative analysis of the rabbit alpha-like globin gene cluster reveals a rapid mode of evolution in a G + C-rich region of mammalian genomes.J Mol Biol. 1991 Nov 20;222(2):233-49. doi: 10.1016/0022-2836(91)90209-o. J Mol Biol. 1991. PMID: 1960725
-
Use of long sequence alignments to study the evolution and regulation of mammalian globin gene clusters.Mol Biol Evol. 1993 Jan;10(1):73-102. doi: 10.1093/oxfordjournals.molbev.a039991. Mol Biol Evol. 1993. PMID: 8383794 Review.
-
Complete nucleotide sequence of the rabbit beta-like globin gene cluster: insights into evolution and regulation.Prog Clin Biol Res. 1989;316B:1-17. Prog Clin Biol Res. 1989. PMID: 2694173 Review.
Cited by
-
Differential loss of embryonic globin genes during the radiation of placental mammals.Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):12950-5. doi: 10.1073/pnas.0804392105. Epub 2008 Aug 28. Proc Natl Acad Sci U S A. 2008. PMID: 18755893 Free PMC article.
-
Fate of a redundant gamma-globin gene in the atelid clade of New World monkeys: implications concerning fetal globin gene expression.Proc Natl Acad Sci U S A. 1995 Mar 28;92(7):2607-11. doi: 10.1073/pnas.92.7.2607. Proc Natl Acad Sci U S A. 1995. PMID: 7535927 Free PMC article.
-
Atypical regions in large genomic DNA sequences.Proc Natl Acad Sci U S A. 1994 Jul 19;91(15):7134-8. doi: 10.1073/pnas.91.15.7134. Proc Natl Acad Sci U S A. 1994. PMID: 8041759 Free PMC article.
-
Multiple L1 progenitors in prosimian primates: phylogenetic evidence from ORF1 sequences.J Mol Evol. 1993 Aug;37(2):179-89. doi: 10.1007/BF02407354. J Mol Evol. 1993. PMID: 8411207
-
Phylogenetic comparisons suggest that distance from the locus control region guides developmental expression of primate beta-type globin genes.Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3186-91. doi: 10.1073/pnas.0511347103. Epub 2006 Feb 17. Proc Natl Acad Sci U S A. 2006. PMID: 16488971 Free PMC article.
Publication types
MeSH terms
Substances
Associated data
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
