Stats: multifaceted regulators of transcription
- PMID: 16375601
- DOI: 10.1089/jir.2005.25.733
Stats: multifaceted regulators of transcription
Abstract
The high-affinity binding interactions between interferons (IFNs) and their cognate cell surface receptors lead to the activation of receptor-associated Janus protein tyrosine kinases (Jaks) and subsequent phosphorylation and activation of a group of transcription factors, the signal transducers and activators of transcription (Stats). Upon IFN-induced activation, these Stat proteins form homodimeric and heterodimeric complexes that translocate to the nucleus and bind specific elements within the promoters of IFN-stimulated genes (ISGs). In addition to the well-studied IFN-induced ISG factor 3 (ISGF3) and Stat1:1 complexes, IFNs induce the formation of a number of other Stat-containing complexes, including Stat3:3 and Stat5:5 homodimers, as well as Stat2:1 and Stat5:CrkL heterodimers, that also mediate gene transcription. Moreover, emerging evidence suggests that particular amino acid residues within the individual Stat proteins contribute to different aspects of Stat function. These residues modulate the transcriptional activation potential of Stat-containing complexes and thereby influence the expression of ISGs. Indeed, the Stat proteins function in a multifaceted manner to regulate the expression of proteins that mediate IFN responses.
Similar articles
-
STAT activation and differential complex formation dictate selectivity of interferon responses.Acta Biochim Pol. 2007;54(1):27-38. Epub 2007 Mar 9. Acta Biochim Pol. 2007. PMID: 17351669 Review.
-
Genomic DNA affinity chromatography: a technique to isolate interferon-inducible DNA binding factors.Methods Mol Med. 2005;116:57-67. doi: 10.1385/1-59259-939-7:057. Methods Mol Med. 2005. PMID: 16000854
-
Prolactin activates Stat1 but does not antagonize Stat1 activation and growth inhibition by type I interferons in human breast cancer cells.Cancer Res. 1998 May 1;58(9):1914-9. Cancer Res. 1998. PMID: 9581833
-
[Interferon signaling pathways].Bull Cancer. 1999 Nov;86(11):911-9. Bull Cancer. 1999. PMID: 10586107 French.
-
The role of STATs in transcriptional control and their impact on cellular function.Oncogene. 2000 May 15;19(21):2468-73. doi: 10.1038/sj.onc.1203476. Oncogene. 2000. PMID: 10851045 Review.
Cited by
-
Methamphetamine facilitates HIV infection of primary human monocytes through inhibiting cellular viral restriction factors.Cell Biosci. 2021 Nov 10;11(1):194. doi: 10.1186/s13578-021-00703-4. Cell Biosci. 2021. PMID: 34758885 Free PMC article.
-
Determinants of Ligand Specificity and Functional Plasticity in Type I Interferon Signaling.Front Immunol. 2021 Oct 7;12:748423. doi: 10.3389/fimmu.2021.748423. eCollection 2021. Front Immunol. 2021. PMID: 34691060 Free PMC article.
-
Structural basis for STAT2 suppression by flavivirus NS5.Nat Struct Mol Biol. 2020 Oct;27(10):875-885. doi: 10.1038/s41594-020-0472-y. Epub 2020 Aug 10. Nat Struct Mol Biol. 2020. PMID: 32778820 Free PMC article.
-
Transcriptional insights into the CD8+ T cell response in mono-HIV and HCV infection.J Transl Med. 2020 Feb 24;18(1):96. doi: 10.1186/s12967-020-02252-9. J Transl Med. 2020. PMID: 32093694 Free PMC article.
-
Nonstructural Protein 11 of Porcine Reproductive and Respiratory Syndrome Virus Induces STAT2 Degradation To Inhibit Interferon Signaling.J Virol. 2019 Oct 29;93(22):e01352-19. doi: 10.1128/JVI.01352-19. Print 2019 Nov 15. J Virol. 2019. PMID: 31462568 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials
Miscellaneous
