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Review
. 2006 Jan;8(1):11-29.
doi: 10.1111/j.1745-7262.2006.00112.x.

Sperm chromatin structure and male fertility: biological and clinical aspects

J Erenpreiss  1 , M Spano, J Erenpreisa, M Bungum, A Giwercman
Affiliations
Free article
Review

Sperm chromatin structure and male fertility: biological and clinical aspects

J Erenpreiss et al. Asian J Androl. 2006 Jan.
Free article

Abstract

Sperm chromatin/DNA integrity is essential for the accurate transmission of paternal genetic information, and normal sperm chromatin structure is important for sperm fertilizing ability. The routine examination of semen, which includes sperm concentration, motility and morphology, does not identify defects in sperm chromatin structure. The origin of sperm DNA damage and a variety of methods for its assessment are described. Evaluation of sperm DNA damage appears to be a useful tool for assessing male fertility potential both in vivo and in vitro. The possible impact of sperm DNA defects on the offspring is also discussed.

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