Review
doi: 10.3816/CLC.2005.n.040.
The role of mitogen-activated ERK-kinase inhibitors in lung cancer therapy
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- PMID: 16354319
- DOI: 10.3816/CLC.2005.n.040
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Review
The role of mitogen-activated ERK-kinase inhibitors in lung cancer therapy
Clin Lung Cancer.
2005 Nov.
Abstract
The Ras-Raf-MAPK pathway has been implicated in lung carcinogenesis and, potentially, the maintenance of the malignant phenotype in these tumors. Mutations in ras and B-raf genes have been described in lung cancer, representing one of the few examples of tandem mutations in a signaling cascade. As a result, numerous approaches to inhibiting this pathway in lung cancer have been explored in the past decade. The most promising approach to date appears to be the inhibition of mitogen-activated ERK kinase or MEK. In this review, the potential utility of MEK inhibitors in the therapy of lung cancer is discussed.
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