Review
doi: 10.2165/00128071-200506060-00003.
Monitoring liver function during methotrexate therapy for psoriasis: are routine biopsies really necessary?
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- PMID: 16343024
- DOI: 10.2165/00128071-200506060-00003
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Review
Monitoring liver function during methotrexate therapy for psoriasis: are routine biopsies really necessary?
Am J Clin Dermatol.
2005.
Abstract
Methotrexate is a widely used and efficacious treatment for psoriasis. Current recommendations advise liver biopsy after each cumulative 1-1.5g dosage of methotrexate. Although studies of methotrexate hepatotoxicity in psoriasis are of variable quality, the evidence indicates that in patients with no risk factors for liver disease on long-term, low-dosage (<20mg), once-weekly methotrexate, liver biopsy is justified after an initial cumulative dosage of 4g. Advances in the non-invasive assessment of liver fibrogenesis may eventually further reduce the need for biopsy.
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