doi: 10.1126/science.1118357.
Increase in activity during calorie restriction requires Sirt1
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- PMID: 16339438
- DOI: 10.1126/science.1118357
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Increase in activity during calorie restriction requires Sirt1
Science.
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Abstract
Sir2 (silent information regulator 2) is a nicotinamide adenine dinucleotide-dependent deacetylase required for longevity due to calorie restriction in yeast and Drosophila. In mammals, calorie restriction induces a complex pattern of physiological and behavioral changes. Here we report that the mammalian Sir2 ortholog, Sirt1, is required for the induction of a phenotype by calorie restriction in mice.
Comment in
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Smaller, hungrier mice.Science. 2006 Mar 17;311(5767):1553-4; author reply 1553-4. doi: 10.1126/science.311.5767.1553. Science. 2006. PMID: 16543441 No abstract available.
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