Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1992 Aug;66(8):5141-6.
doi: 10.1128/JVI.66.8.5141-5146.1992.

Determinants of thymotropism in Kaplan radiation leukemia virus and nucleotide sequence of its envelope region

L Poliquin  1 , D Bergeron, J L Fortier, Y Paquette, R Bergeron, E Rassart
Affiliations
Comparative Study

Determinants of thymotropism in Kaplan radiation leukemia virus and nucleotide sequence of its envelope region

L Poliquin et al. J Virol. 1992 Aug.

Abstract

Radiation leukemia viruses (RadLVs) are a group of murine leukemia viruses which are induced by radiation and cause T-cell leukemia. Viral clones isolated from the BL/VL3 lymphoid cell line derived from a thymoma show variable tropism and leukemogenic potential. We have constructed chimeric viruses by in vitro recombination between two viruses, a RadLV that is thymotropic and an endogenous ecotropic virus that is nonthymotropic. We show here that, in contrast to thymotropism determinants identified previously, which lie in the long terminal repeat (LTR), it is the envelope region that is responsible for the thymotropism of BL/VL3 RadLV. The nonthymotropic virus which we have rendered thymotropic by transfer of the env region of RadLV in the present study has been shown previously to become thymotropic when the LTR of another thymotropic virus is inserted in its genome. Thus, the LTR and envelope gene may be involved in complementary action to lead to thymotropism.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Natl Cancer Inst Monogr. 1964 May;14:207-20 - PubMed
    1. J Virol. 1983 Apr;46(1):70-82 - PubMed
    1. J Virol. 1988 Oct;62(10):3840-8 - PubMed
    1. J Virol. 1986 Apr;58(1):96-106 - PubMed
    1. J Virol. 1985 Jan;53(1):158-65 - PubMed

Publication types

MeSH terms

Associated data