Skip to main page content
U.S. flag

An official website of the United States government

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2006 Mar 10;113(1-2):83-7.
doi: 10.1016/j.vetmic.2005.10.014. Epub 2005 Nov 16.

Analysis of the matrix protein gene sequence of the Asian lineage of peste-des-petits ruminants vaccine virus

Affiliations
Comparative Study

Analysis of the matrix protein gene sequence of the Asian lineage of peste-des-petits ruminants vaccine virus

D Muthuchelvan et al. Vet Microbiol. .

Abstract

The M gene nucleotide sequence of an Indian peste-des-petits ruminants (PPRV) vaccine virus ("PPRV Sungri/96") belonging to Asian lineage was determined. The gene is 1476 nucleotides long with a single open reading frame (ORF). The nucleotide and predicted amino acid sequence was compared with the homologous region of the African Lineage Vaccine virus "PPRV/Nigeria/75/1". The nucleotide sequence of the "PPRV Sungri/96" was 86% identical to that of "PPRV/Nigeria/75/1", while a homology of 93% and 95% could be observed in the ORF and amino acids level, respectively. The M gene encodes a protein of 335 amino acids, with a predicted molecular weight (MW) of 37.8 kDa. The ORF is flanked by a 3' untranslated region of 436 nucleotides and a high level of sequence divergence (approximately 30%) could be observed in this region between the vaccine viruses of Asian and African lineages. A high degree of conservation of several amino acids of this protein observed previously was also confirmed in this study.

PubMed Disclaimer

Similar articles

Cited by

Publication types

MeSH terms

Associated data

LinkOut - more resources