Molecular determinants of biocompatibility
- PMID: 16293087
- DOI: 10.1586/17434440.2.4.493
Molecular determinants of biocompatibility
Abstract
The biocompatibility of medical implants dictates the fate of almost all medical devices. It is well established that medical devices trigger a variety of adverse tissue responses, such as inflammation, fibrosis, infection and thrombosis. However, the mechanisms involved in biomaterial-mediated tissue responses remain largely unknown. The lack of such knowledge hinders the development of biomaterials with better biocompatibility and safety. The aim of this review is to summarize our current understanding of the processes governing foreign body reactions to tissue-contact devices. Obviously, this information is urgently needed for assisting the rational design of materials or medical devices to minimize undesirable tissue reactions upon implantation and, in addition, to promote the wound healing process.
Similar articles
-
Foreign body reaction to biomaterials.Semin Immunol. 2008 Apr;20(2):86-100. doi: 10.1016/j.smim.2007.11.004. Epub 2007 Dec 26. Semin Immunol. 2008. PMID: 18162407 Free PMC article. Review.
-
[Advances in interaction of macrophages with tissue engineering related biomaterials].Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2008 Apr;25(2):487-90. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2008. PMID: 18610649 Review. Chinese.
-
Biocompatibility--the interaction of biomaterials and host response.J Dent Educ. 1988 Dec;52(12):798-803. J Dent Educ. 1988. PMID: 3057026 Review.
-
Adverse cutaneous reactions to soft tissue fillers--a review of the histological features.J Cutan Pathol. 2008 Jun;35(6):536-48. doi: 10.1111/j.1600-0560.2007.00853.x. Epub 2008 Jan 14. J Cutan Pathol. 2008. PMID: 18201242 Review.
-
The role of TGF-beta1 as a determinant of foreign body reaction to alloplastic materials in rat fibroblast cultures: comparison of different commercially available polypropylene meshes for hernia repair.Regul Pept. 2007 Jan 10;138(1):10-4. doi: 10.1016/j.regpep.2006.07.010. Epub 2006 Sep 12. Regul Pept. 2007. PMID: 16973225
Cited by
-
Stability analysis of a model for foreign body fibrotic reactions.Comput Math Methods Med. 2012;2012:809864. doi: 10.1155/2012/809864. Epub 2012 Sep 13. Comput Math Methods Med. 2012. PMID: 23193430 Free PMC article.
-
Focus on collagen: in vitro systems to study fibrogenesis and antifibrosis state of the art.Fibrogenesis Tissue Repair. 2009 Dec 15;2:7. doi: 10.1186/1755-1536-2-7. Fibrogenesis Tissue Repair. 2009. PMID: 20003476 Free PMC article.
-
Aluminum adjuvants elicit fibrin-dependent extracellular traps in vivo.Blood. 2010 Dec 9;116(24):5191-9. doi: 10.1182/blood-2010-03-275529. Epub 2010 Sep 27. Blood. 2010. PMID: 20876456 Free PMC article.
-
Macrophages, Foreign Body Giant Cells and Their Response to Implantable Biomaterials.Materials (Basel). 2015 Aug 28;8(9):5671-5701. doi: 10.3390/ma8095269. Materials (Basel). 2015. PMID: 28793529 Free PMC article. Review.
-
In vivo evaluation of medical device-associated inflammation using a macrophage-specific positron emission tomography (PET) imaging probe.Bioorg Med Chem Lett. 2013 Apr 1;23(7):2044-7. doi: 10.1016/j.bmcl.2013.02.004. Epub 2013 Feb 13. Bioorg Med Chem Lett. 2013. PMID: 23481649 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
