The human T-cell leukemia virus type 1 (HTLV-1): new insights into the clinical aspects and molecular pathogenesis of adult T-cell leukemia/lymphoma (ATLL) and tropical spastic paraparesis/HTLV-associated myelopathy (TSP/HAM)
- PMID: 16276549
- DOI: 10.1002/jemt.20231
The human T-cell leukemia virus type 1 (HTLV-1): new insights into the clinical aspects and molecular pathogenesis of adult T-cell leukemia/lymphoma (ATLL) and tropical spastic paraparesis/HTLV-associated myelopathy (TSP/HAM)
Abstract
Human T-cell leukemia virus type 1 (HTLV-1) was the first human retrovirus to be identified in the early 1980s. The isolation and identification of a related virus, HTLV-2, and the distantly related human immunodeficiency virus (HIV) immediately followed. Of the three retroviruses, two are associated definitively with specific diseases, HIV, with acquired immune deficiency syndrome (AIDS) and HTLV-1, with adult T-cell leukemia/lymphoma (ATLL) and tropical spastic paraparesis/HTLV-1-associated myelopathy (TSP/HAM). While an estimated 10-20 million people worldwide are infected with HTLV-I, infection is endemic in the Caribbean, parts of Africa, southwestern Japan, and Italy. Approximately 4% of HTLV-I infected individuals develop ATLL, a disease with a poor prognosis. The clinical manifestations of infection and the current biology of HTLV viruses with emphasis on HTLV-1 are discussed in detail. The implications for improvements in diagnosis, treatment, intervention, and vaccination are included, as well as a discussion of the emergence of HTLV-1 and -2 as copathogens among HIV-1-infected individuals.
2005 Wiley-Liss, Inc.
Similar articles
-
Tropical spastic paraparesis and HTLV-1 associated myelopathy: clinical, epidemiological, virological and therapeutic aspects.Rev Neurol (Paris). 2012 Mar;168(3):257-69. doi: 10.1016/j.neurol.2011.12.006. Epub 2012 Mar 7. Rev Neurol (Paris). 2012. PMID: 22405461 Review.
-
Tropical spastic paraparesis/human T leukemia virus type 1-associated myelopathy in HIV type 1-coinfected patients.Clin Infect Dis. 2005 Sep 15;41(6):e57-63. doi: 10.1086/432890. Epub 2005 Jul 29. Clin Infect Dis. 2005. PMID: 16107970
-
Differential patterns of serum biomarkers of immune activation in human T-cell lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis, and adult T-cell leukemia/lymphoma.Cancer Epidemiol Biomarkers Prev. 1996 Sep;5(9):699-704. Cancer Epidemiol Biomarkers Prev. 1996. PMID: 8877061
-
Sequence analysis of an immunogenic and neutralizing domain of the human T-cell lymphoma/leukemia virus type I gp46 surface membrane protein among various primate T-cell lymphoma/leukemia virus isolates including those from a patient with both HTLV-I-associated myelopathy and adult T-cell leukemia.Cancer Res. 1993 Dec 15;53(24):6067-73. Cancer Res. 1993. PMID: 8261424
-
[Human retrovirus HTLV-1: descriptive and molecular epidemiology, origin, evolution, diagnosis and associated diseases].Bull Soc Pathol Exot. 2011 Aug;104(3):167-80. doi: 10.1007/s13149-011-0174-4. Epub 2011 Jul 27. Bull Soc Pathol Exot. 2011. PMID: 21796326 Review. French.
Cited by
-
Human T cell leukemia virus type 1 and Zika virus: tale of two reemerging viruses with neuropathological sequelae of public health concern.J Neurovirol. 2019 Jun;25(3):289-300. doi: 10.1007/s13365-019-00720-7. Epub 2019 Jan 28. J Neurovirol. 2019. PMID: 30693421 Review.
-
Assessment of HTLV-1 proviral load, LAT, BIM, c-FOS and RAD51 gene expression in adult T cell leukemia/lymphoma.Med Microbiol Immunol. 2017 Aug;206(4):327-335. doi: 10.1007/s00430-017-0506-1. Epub 2017 May 2. Med Microbiol Immunol. 2017. PMID: 28466382
-
TAX and HBZ: hFc Ɣ 1 proteins as targets for passive immunotherapy.Iran J Basic Med Sci. 2022 May;25(5):586-596. doi: 10.22038/IJBMS.2022.64787.14266. Iran J Basic Med Sci. 2022. PMID: 35911645 Free PMC article.
-
Cutaneous epitheliotropic lymphoma in a baboon (Papio spp.): A case report and a brief literature review.J Med Primatol. 2019 Jun;48(3):192-196. doi: 10.1111/jmp.12410. Epub 2019 Apr 2. J Med Primatol. 2019. PMID: 30941777 Free PMC article. Review.
-
Recombinant human T-cell leukemia virus types 1 and 2 Tax proteins induce high levels of CC-chemokines and downregulate CCR5 in human peripheral blood mononuclear cells.Viral Immunol. 2011 Dec;24(6):429-39. doi: 10.1089/vim.2011.0037. Epub 2011 Nov 23. Viral Immunol. 2011. PMID: 22111594 Free PMC article.
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Miscellaneous
