Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2005 Oct 28;310(5748):644-8.
doi: 10.1126/science.1117679.

Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer

Scott A Tomlins  1 , Daniel R Rhodes, Sven Perner, Saravana M Dhanasekaran, Rohit Mehra, Xiao-Wei Sun, Sooryanarayana Varambally, Xuhong Cao, Joelle Tchinda, Rainer Kuefer, Charles Lee, James E Montie, Rajal B Shah, Kenneth J Pienta, Mark A Rubin, Arul M Chinnaiyan
Affiliations

Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer

Scott A Tomlins et al. Science. .

Abstract

Recurrent chromosomal rearrangements have not been well characterized in common carcinomas. We used a bioinformatics approach to discover candidate oncogenic chromosomal aberrations on the basis of outlier gene expression. Two ETS transcription factors, ERG and ETV1, were identified as outliers in prostate cancer. We identified recurrent gene fusions of the 5' untranslated region of TMPRSS2 to ERG or ETV1 in prostate cancer tissues with outlier expression. By using fluorescence in situ hybridization, we demonstrated that 23 of 29 prostate cancer samples harbor rearrangements in ERG or ETV1. Cell line experiments suggest that the androgen-responsive promoter elements of TMPRSS2 mediate the overexpression of ETS family members in prostate cancer. These results have implications in the development of carcinomas and the molecular diagnosis and treatment of prostate cancer.

PubMed Disclaimer

Comment in

Similar articles

See all similar articles

Cited by

  • From bedside to bench: regulation of host factors in SARS-CoV-2 infection.
    Ong SYQ, Flyamer IM, Bickmore WA, Biddie SC. Ong SYQ, et al. Exp Mol Med. 2021 Apr;53(4):483-494. doi: 10.1038/s12276-021-00595-x. Epub 2021 Apr 7. Exp Mol Med. 2021. PMID: 33828231 Free PMC article. Review.
  • Sex hormones, autoimmunity and gender disparity in COVID-19.
    Raza HA, Sen P, Bhatti OA, Gupta L. Raza HA, et al. Rheumatol Int. 2021 Aug;41(8):1375-1386. doi: 10.1007/s00296-021-04873-9. Epub 2021 Apr 26. Rheumatol Int. 2021. PMID: 33903964 Free PMC article. Review.
  • Development and validation of a scalable next-generation sequencing system for assessing relevant somatic variants in solid tumors.
    Hovelson DH, McDaniel AS, Cani AK, Johnson B, Rhodes K, Williams PD, Bandla S, Bien G, Choppa P, Hyland F, Gottimukkala R, Liu G, Manivannan M, Schageman J, Ballesteros-Villagrana E, Grasso CS, Quist MJ, Yadati V, Amin A, Siddiqui J, Betz BL, Knudsen KE, Cooney KA, Feng FY, Roh MH, Nelson PS, Liu CJ, Beer DG, Wyngaard P, Chinnaiyan AM, Sadis S, Rhodes DR, Tomlins SA. Hovelson DH, et al. Neoplasia. 2015 Apr;17(4):385-99. doi: 10.1016/j.neo.2015.03.004. Neoplasia. 2015. PMID: 25925381 Free PMC article.
  • Sequence analysis of mutations and translocations across breast cancer subtypes.
    Banerji S, Cibulskis K, Rangel-Escareno C, Brown KK, Carter SL, Frederick AM, Lawrence MS, Sivachenko AY, Sougnez C, Zou L, Cortes ML, Fernandez-Lopez JC, Peng S, Ardlie KG, Auclair D, Bautista-Piña V, Duke F, Francis J, Jung J, Maffuz-Aziz A, Onofrio RC, Parkin M, Pho NH, Quintanar-Jurado V, Ramos AH, Rebollar-Vega R, Rodriguez-Cuevas S, Romero-Cordoba SL, Schumacher SE, Stransky N, Thompson KM, Uribe-Figueroa L, Baselga J, Beroukhim R, Polyak K, Sgroi DC, Richardson AL, Jimenez-Sanchez G, Lander ES, Gabriel SB, Garraway LA, Golub TR, Melendez-Zajgla J, Toker A, Getz G, Hidalgo-Miranda A, Meyerson M. Banerji S, et al. Nature. 2012 Jun 20;486(7403):405-9. doi: 10.1038/nature11154. Nature. 2012. PMID: 22722202 Free PMC article.
  • PTEN, ERG, SPINK1, and TFF3 Status and Relationship in a Prostate Cancer Cohort from Jordanian Arab Population.
    Al Bashir S, Alorjani MS, Kheirallah K, Al Hamad M, Haddad HK, Al-Dwairy A, Bani-Fawwaz BA, Aldaoud N, Halalsheh O, Amawi S, Matalka II. Al Bashir S, et al. Medicina (Kaunas). 2024 Jan 18;60(1):174. doi: 10.3390/medicina60010174. Medicina (Kaunas). 2024. PMID: 38256434 Free PMC article.
See all "Cited by" articles

Publication types

MeSH terms

Associated data