The pleiotropic role of autophagy: from protein metabolism to bactericide
- PMID: 16247501
- DOI: 10.1038/sj.cdd.4401728
The pleiotropic role of autophagy: from protein metabolism to bactericide
Abstract
Autophagy is in principle a nonselective, bulk degradation system within cells, with a contribution to intracellular protein degradation estimated to be as large as that of the ubiquitin--proteasome system. The primary roles of autophagy are baseline turnover of intracellular proteins and organelles, production of amino acids in nutrient emergency, and regression of retired tissues. These functions guarantee rejuvenation and adaptation to adverse conditions, and even underlie dynamic processes such as development/metamorphosis. In addition, several other roles for autophagy have recently been discovered, such as presentation of endogenous antigens and degradation of invasive bacteria. This review will discuss the biological significance of autophagy from yeast to higher eukaryotes.
Similar articles
-
Emerging roles for the ubiquitin-proteasome system and autophagy in pancreatic beta-cells.Am J Physiol Endocrinol Metab. 2009 Jan;296(1):E1-10. doi: 10.1152/ajpendo.90538.2008. Epub 2008 Sep 23. Am J Physiol Endocrinol Metab. 2009. PMID: 18812463 Review.
-
Hsp90 inhibition results in autophagy-mediated proteasome-independent degradation of IkappaB kinase (IKK).Cell Res. 2006 Nov;16(11):895-901. doi: 10.1038/sj.cr.7310109. Cell Res. 2006. PMID: 17088896
-
The role of autophagy in age-related neurodegeneration.Neurosignals. 2008;16(1):75-84. doi: 10.1159/000109761. Epub 2007 Dec 5. Neurosignals. 2008. PMID: 18097162 Review.
-
Role of the proteasome in ethanol-induced liver pathology.Alcohol Clin Exp Res. 2007 Sep;31(9):1446-59. doi: 10.1111/j.1530-0277.2007.00454.x. Alcohol Clin Exp Res. 2007. PMID: 17760783 Review.
-
Physiological significance of selective degradation of p62 by autophagy.FEBS Lett. 2010 Apr 2;584(7):1374-8. doi: 10.1016/j.febslet.2010.02.017. Epub 2010 Feb 12. FEBS Lett. 2010. PMID: 20153326 Review.
Cited by
-
S6K1 Is Indispensible for Stress-Induced Microtubule Acetylation and Autophagic Flux.Cells. 2021 Apr 17;10(4):929. doi: 10.3390/cells10040929. Cells. 2021. PMID: 33920542 Free PMC article.
-
Autophagy lessens ischemic liver injury by reducing oxidative damage.Cell Biosci. 2013 Jun 10;3(1):26. doi: 10.1186/2045-3701-3-26. Cell Biosci. 2013. PMID: 23758862 Free PMC article.
-
Gene expression profiling identifies FKBP39 as an inhibitor of autophagy in larval Drosophila fat body.Cell Death Differ. 2007 Jun;14(6):1181-90. doi: 10.1038/sj.cdd.4402123. Epub 2007 Mar 16. Cell Death Differ. 2007. PMID: 17363962 Free PMC article.
-
Endoplasmic reticulum stress triggers autophagy.J Biol Chem. 2006 Oct 6;281(40):30299-304. doi: 10.1074/jbc.M607007200. Epub 2006 Aug 10. J Biol Chem. 2006. PMID: 16901900 Free PMC article.
-
Integration of clearance mechanisms: the proteasome and autophagy.Cold Spring Harb Perspect Biol. 2010 Dec;2(12):a006734. doi: 10.1101/cshperspect.a006734. Epub 2010 Nov 10. Cold Spring Harb Perspect Biol. 2010. PMID: 21068151 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Molecular Biology Databases
