Review
doi: 10.1042/BST0331375.
Thiol redox control via thioredoxin and glutaredoxin systems
Affiliations
- PMID: 16246122
- DOI: 10.1042/BST0331375
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Review
Thiol redox control via thioredoxin and glutaredoxin systems
Biochem Soc Trans.
2005 Dec.
Abstract
The Trx (thioredoxin) and Grx (glutaredoxin) systems control cellular redox potential, keeping a reducing thiol-rich intracellular state, which on generation of reactive oxygen species signals through thiol redox control mechanisms. Here, we give a brief overview of the human Trx and Grx systems. The main part focuses on our current knowledge about mitochondrial Grx2, which facilitates mitochondrial redox homoeostasis during oxidative stress-induced apoptosis.
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