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Review
. 2006 Jan 28;232(1):70-8.
doi: 10.1016/j.canlet.2005.07.040. Epub 2005 Oct 17.

Chromatin structure of human chromosomal fragile sites

Yuh-Hwa Wang  1
Affiliations
Review

Chromatin structure of human chromosomal fragile sites

Yuh-Hwa Wang. Cancer Lett. .

Abstract

Cytological appearance of fragile sites as non-staining gaps in metaphase chromosomes suggests an abnormality in chromatin structure. Studies of fragile sites at three levels of chromosome organization: (1) examining the ability of DNA derived from fragile sites to form nucleosomes-the basic structural element of chromosomes, (2) probing the arrangement of nucleosome arrays over fragile sites in fragile site-expressing cell lines, and (3) visualizing fragile sites in higher-order chromatin organization, reveal an unusual chromatin structure associated with fragile sites. This fragile site-associated chromatin structure might play an active role in DNA metabolic processes such as replication, transcription, repair and recombination, which are closely linked to the instability of fragile sites.

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